| 谢伟,李宗芳,赵卫,张振光,蒋元明,王清,张荟美.静息态fMRI观察特发性三叉神经痛患者脑内自发性活动[J].中国医学影像技术,2016,32(7):1020~1025 |
| 静息态fMRI观察特发性三叉神经痛患者脑内自发性活动 |
| Resting state fMRI in observation of altered brain spontaneous activity in patients with idiopathic trigeminal neuralgia |
| 投稿时间：2015-11-23 修订日期：2016-04-02 |
| DOI：10.13929/j.1003-3289.2016.07.008 |
| 中文关键词: 三叉神经痛 磁共振成像 低频振幅 |
| 英文关键词:Trigeminal neuralgia Magnetic resonance imaging Amplitude of low frequency fluctuation |
| 基金项目:云南省应用基础研究（昆医联合专项）（2013FB130）、云南省教育厅科学研究基金项目(2013Y280)昆明医科大学研究生创新基金（2015S78） |
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| 中文摘要: |
| 目的 探讨特发性三叉神经痛（ITN）患者脑内神经元自发性活动的变化。方法 对左侧ITN（LITN组）18例、右侧ITN（RITN组）22例患者及正常对照（HC）组36名受检者分别行静息态fMRI （R-fMRI），比较3组低频振幅（ALFF）的差异。结果 与HC组比较，LITN组右侧丘脑、中脑导水管周围灰质及双侧中后扣带回ALFF值减低（P均<0.01），RITN组左侧丘脑、左侧楔前叶、左侧颞上回及左侧小脑半球ALFF值减低，双侧前额叶ALFF值增加（P均<0.01）。与RITN组比较，LITN组左侧中央前回ALFF值减低，左侧楔前叶及左侧楔叶ALFF值增加（P均<0.01）。结论 静息状态下ITN患者脑内多个脑区ALFF值发生变化，表明相关脑区存在神经元的异常活动，其可能与人脑对慢性疼痛的调控及适应性改变有关。 |
| 英文摘要: |
| Objective To explore the changes of brain neurons spontaneous activity in patients with idiopathic trigeminal neuralgia (ITN). Methods The resting state fMRI (R-fMRI) data from left ITN (LITN) group (n=18), right ITN (RITN) group (n=22) and healthy control (HC) group (n=36) were acquired, and the values of amplitude of low frequency fluctuation (ALFF) among the three groups were compared. Results Compared with HC gruop, LITN group showed decreased ALFF values in right thalamus, periaqueductal gray and bilateral posterior midcingulate cortex (all P<0.01), RITN group showed decreased ALFF values in left thalamus, left precuneus, left superior temporal gyrus and left cerebellum, increased ALFF values in bilateral prefrontal (all P<0.01). Compared with RITN group, LITN group showed decreased ALFF values in left precentral gyrus, increased ALFF values in left precuneus and left cuneus (all P<0.01). Conclusion Under resting state, the ALFF values have changed in multiple brain areas of the ITN patients, and can be used to reflect abnormal spontaneous activity of neurons, which may be related with chronic pain regulation and adaptability. |
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