| 王渊,李丹,包发秀,麻少辉,NETRA Rana,张明.多体素1H-MRS观察原发性三叉神经痛患者丘脑代谢异常[J].中国医学影像技术,2014,30(3):339~343 |
| 多体素1H-MRS观察原发性三叉神经痛患者丘脑代谢异常 |
| Multi-voxel 1H-MRS in observation on metabolic abnormalities of thalamus in patients with idiopathic trigeminal neuralgia |
| 投稿时间：2013-10-27 修订日期：2014-02-10 |
| DOI： |
| 中文关键词: 磁共振波谱 三叉神经痛 丘脑 视觉模拟评分 |
| 英文关键词:Magnetic resonance spectroscopy Trigeminal neuralgia Thalamus Visual analogue scale |
| 基金项目:国家自然科学基金（81301207、81371530）。 |
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| 摘要点击次数: 1998 |
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| 中文摘要: |
| 目的 采用多体素1H-MRS分析原发性三叉神经痛（ITN）患者丘脑各亚区主要代谢物改变及其与临床病情的关系。方法 选取丘脑前部、板内区、后外侧部及后内侧部作为ROI进行1H-MRS扫描，获取N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）峰下面积，计算患者组和正常对照组的NAA/Cr以及Cho/Cr比值，同时记录视觉模拟评分（VAS），以便为影像学发现提供支持。 结果 与对照组比较，患者组患侧丘脑后外侧部及后内侧部NAA/Cr比值有所降低，患侧丘脑板内区NAA/Cr及Cho/Cr比值亦低于对照组；其中患侧丘脑后内侧部NAA/Cr比值与VAS评分（r=－0.58，P<0.01）及病程（r=－0.48，P<0.05）呈显著负相关。结论 ITN患者丘脑部分亚区代谢物存在异常；检测患侧丘脑后内侧部NAA/Cr比值可能反映疼痛程度。 |
| 英文摘要: |
| Objective To observe metabolic changes in sub-regions of thalamus in patients with idiopathic trigeminal neuralgia (ITN) using multi-voxel proton magnetic resonance spectroscopy (1H-MRS). Methods ROIs were located in the anterior thalamus (a-Th), intralaminar portion of thalamus (IL-Th), posterior lateral thalamus (pl-Th) and posterior medial thalamus (pm-Th). N-Acetylaspartate to creatine (NAA/Cr) and choline to creatine (Cho/Cr) ratios were measured in ITN and control groups. Visual analog scale (VAS) was also recorded as the proofs of neuroradiological findings. Results NAA/Cr ratio in the contralateral pm-Th and pl-Th with ITN patients were significantly lower than that in the same portions of the controls. Meanwhile, decrease of NAA/Cr and Cho/Cr were detected in IL-Th of ITN patients. Furthermore, NAA/Cr ratio in the contralateral pm-Th was negatively associated with the value of VAS (r=－0.58, P<0.01) and disease duration (r=－0.48, P<0.05), respectively. Conclusion There are biochemical changes in several thalamic sub-regions in patients with ITN. Low level of NAA/Cr in pm-Th probably serves as a marker of the pain-rating index. |
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