| 孟凡星,卢再鸣*,周萌萌,彭淼,于兵,郭启勇.慢性疲劳综合征患儿的全脑功能连接异常[J].中国医学影像技术,2014,30(1):34~37 |
| 慢性疲劳综合征患儿的全脑功能连接异常 |
| Aberrant whole-brain functional connectivity in children with chronic fatigue syndrome |
| 投稿时间：2013-07-25 修订日期：2013-10-10 |
| DOI： |
| 中文关键词: 慢性疲劳综合征 磁共振成像 全脑功能连接 |
| 英文关键词:Chronic fatigue syndrome Magnetic resonance imaging Whole-brain functional connectivity |
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| 中文摘要: |
| 目的 评估慢性疲劳综合征（CFS）患儿静息状态下全脑功能连接异常。方法 对31例CFS患儿（实验组）以及34名健康儿童（对照组），进行静息态fMRI扫描，应用REST软件包进行后处理。两两计算脑区间自发BOLD变化相关系数的z值。应用双尾t检验比较各自的z值来确定实验组与对照组间功能连接的差异。结果 实验组中共发现15个显著的功能连接异常，其中7个脑区功能连接增强，分别为右侧丘脑-右侧内侧前额叶皮层、右侧岛叶-右侧前扣带回皮层、右侧丘脑-右侧岛叶、右侧丘脑-右侧第二躯体感觉皮层、右侧第一躯体感觉皮层-右侧第二躯体感觉皮层、左侧丘脑-左侧内侧前额叶皮层、左侧丘脑-左侧第二躯体感觉皮层，8个脑区功能连接减弱，分别为右侧丘脑-右侧前扣带回皮层、右侧丘脑-右侧壳核、右侧前扣带回皮层-右侧第一躯体感觉皮层、右侧前扣带回皮层-右侧第二躯体感觉皮层、右侧岛叶-右侧第二躯体感觉皮层、左侧丘脑-左侧壳核、左侧第一躯体感觉皮层-左侧岛叶、左侧第一躯体感觉皮层-左侧第二躯体感觉皮层）。结论 内侧前额叶皮层、岛叶、躯体感觉皮质、前扣带回皮层之间的脑区功能连接异常有可能与CFS的发病和进展有关。 |
| 英文摘要: |
| Objective To assess abnormalities of whole-brain functional connectivity in children with chronic fatigue syndrome (CFS) using fMRI. Methods Resting state fMRI data were obtained from 65 children, including 31 CFS (study group) and 34 age-matched healthy controls (control group). fMRI scanning was performed and post-processed using REST software. Comparisons of z-score correlation coefficients between distinct cerebral regions were used to identify altered functional connectivity in CFS children. Individual z-scores were compared with two-tailed t-tests to determine the significance of functional connectivity between the two groups. Results In CFS group, a total of 15 significantly different functional connectivity were identified, including 7 increased areas, i.e. right thalamus-right medial prefrontal cortex(MPFC), right insula-right anterior cingulated cortex (ACC), right thalamus-right insula, right thalamus-right secondary somatosensory cortices (S2), right primary somatosensory cortices (S1)-right S2, left thalamus-left MPFC and left thalamus-left S2, respectively, as well as 8 decreased areas, i.e. right thalamus-right ACC, right thalamus-right putamen, right ACC-right S1, right ACC-right S2, right insula-right S2, left thalamus-left putamen, left S1-left insula and left S1-left S2, respectively. Conclusion The abnormalities of functional connectivity between MPFC, insula, somatosensory cortices and ACC are likely to be involved in the onset and progression of CFS in children. |
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