| 张苏蕾,张建华,王荣福,闫平,陈立新.影响NOD/SCID小鼠淋巴瘤18F-FDG PET摄取的免疫因素分析[J].中国医学影像技术,2012,28(6):1027~1030 |
| 影响NOD/SCID小鼠淋巴瘤18F-FDG PET摄取的免疫因素分析 |
| Analysis of immune factors on uptake of 18F-FDG in lymphoma of NOD/SCID mice |
| 投稿时间：2011-10-24 修订日期：2011-11-21 |
| DOI： |
| 中文关键词: 淋巴瘤 正电子发射型体层摄影术 体层摄影术,X线计算机 18F 氟脱氧葡萄糖 免疫学因素 |
| 英文关键词:Lymphoma Positron-emission tomography Tomography, X-ray computed Fluorodeoxyglucose F18 Immunologic factors |
| 基金项目:国家重点基础研究发展计划(973计划)项目(2006CB705705)、国家自然科学基金(39870241、81071183、30270410)。 |
|
| 摘要点击次数: 2228 |
| 全文下载次数: 874 |
| 中文摘要: |
| 目的 通过比较两种不同类型免疫缺陷动物肿瘤组织的18F-FDG标准摄取值(SUV),初步探讨B、NK细胞免疫与肿瘤组织的相互作用。方法 对NOD/SCID小鼠(T、B、NK免疫联合缺陷)12只,BALB/C裸鼠(无T细胞免疫)12只,分别种植淋巴瘤细胞(A20),成瘤后对各组均经尾静脉注射18F-FDG 8.32~12.02 MBq(225~325 μCi),使用Philips小动物PET进行全身动态和静态扫描,观察B细胞免疫和NK细胞自然杀伤免疫对肿瘤组织摄取18F-FDG的影响,并分析免疫因素在肿瘤摄取18F-FDG中的作用。结果 NOD/SCID小鼠最大SUV(SUVmax)为18.33±3.42,高于BALB/C裸鼠[(9.66±4.15),t=4.981,P<0.01],平均SUV(SUVmean)为11.04±1.40,高于BALB/C裸鼠[(5.47±3.30),t=4.718,P=0.001]。结论 不同免疫状态对小鼠淋巴瘤的18F-FDG摄取水平存在影响。 |
| 英文摘要: |
| Objective To explore the interactions between the B, NK cell-mediated immunity and tumor tissue by comparing the standardized uptake value (SUV) of 18F-FDG uptake of tumor tissue with two different types of immune deficient mice. Methods Twelve NOD/SCID mice (T, B, NK combined immune deficiency) and 12 BALB/C nude mice (no T-cell immunity) were planted lymphoma cells (A20). After the formation of the tumors, all mice were injected with 18F-FDG 8.32—12.02 MBq (225—325 μCi). Whole body dynamic and static scan was performed on Philips Micro-PET to observe the impact of B cells and NK cells on the uptake of 18F-FDG in lymphoma. And the role of immune factors in the tumor uptake of 18F-FDG was analyzed. Results NOD/SCID mice's maximal SUV (SUVmax) was higher (18.33±3.42) than BALB/C nude mice (9.66±4.15, t=4.981, P<0.01), while their mean SUV (SUVmean) was also higher (11.04±1.40) than that of nude mice (5.47±3.30, t=4.718, P=0.01). Conclusion Different immune statuses of mice affect the level of lymphoma uptake of 18F-FDG. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
