| 张霆霆,王莉,李玉华,黄志军,陆建平.胰泌素刺激-磁共振胰胆管成像定量分析猫慢性胰腺炎的胰腺外分泌功能[J].中国医学影像技术,2012,28(3):416~420 |
| 胰泌素刺激-磁共振胰胆管成像定量分析猫慢性胰腺炎的胰腺外分泌功能 |
| Quantitative analysis of pancreatic exocrine function of chronic pancreatitis in cat models with secretin-stimulated magnetic resonance cholangiopancreatography |
| 投稿时间：2011-07-28 修订日期：2011-11-24 |
| DOI： |
| 中文关键词: 胰腺炎,慢性 胰腺外分泌功能 胰泌素 胰胆管造影术,磁共振 猫 |
| 英文关键词:Pancreatitis, chronic Pancreatic exocrine function Secretin Cholangiopancreatography, magnetic resonance Cats |
| 基金项目:国家自然科学基金(81070371)。 |
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| 中文摘要: |
| 目的 探讨胰泌素刺激-磁共振胰胆管成像(S-MRCP)定量评估猫慢性胰腺炎(CP)胰腺外分泌功能的价值。方法 将32只健康成年猫分为实验组(n＝24) 及对照组(n＝8);实验组剖腹行胰管不全结扎,建立CP模型,对照组仅行无菌开腹,不结扎胰管。对实验组分别于建模后3、5、7周分批行S-MRCP检查,每批次8只;对照组于缝合关腹后立即进行检查。S-MRCP检查完成后对动物胰腺进行病理学分析,根据病理结果将实验组分为3个亚组:CP-Ⅰ(轻度CP)、CP-Ⅱ(中度)、CP-Ⅲ(重度CP)。对各组注射胰泌素前、后胃肠道液体量的增加程度(FVID)进行统计学分析。结果 实验组24只中,15只建模成功,CP-Ⅰ、CP-Ⅱ、CP-Ⅲ亚组分别为7、5、3只。注射胰泌素5 min及15 min后实验组整体FVID低于对照组(F＝9.742、13.543,P均<0.05)。对照组与CP-Ⅱ亚组间、对照组与CP-Ⅲ亚组间及CP-Ⅰ与CP-Ⅲ亚组间差异均有统计学意义(P均<0.05);其余各组间差异虽无统计学意义(P均>0.05),但随着胰腺炎程度加重,FVID有逐渐下降趋势。结论 利用S–MRCP可通过测量注射胰泌素前、后胃肠道液体量的变化评价猫CP模型胰腺外分泌功能。 |
| 英文摘要: |
| Objective To assess the value of secretin-stimulated magnetic resonance cholangiopancreatography (S-MRCP) in quantitative analysis of pancreatic exocrine function in chronic pancreatitis (CP) cat models. Methods Thirty-two healthy adult cats were divided into experimental group (n=24) and control group (n=8). Incomplete ligation of pancreatic duct was performed on cats in experimental group in order to establish CP models, while cats in control group received a sham operation. S-MRCP was performed in 3, 5, and 7 weeks after ligation with 8 cats examined at each time point in experimental group. Cats in control group underwent postoperative S-MRCP immediately. After S-MRCP, cats in experimental group were classified into three subgroups according to the histological analysis of the pancreas: CP-Ⅰ (slight), CP-Ⅱ (moderate) and CP-Ⅲ (severe). Increasing degrees of fluid volume (FVID) in gastrointestinal tract before and after injecting secretin were statistically analyzed. Results Fifteen CP models were established successfully in experimental group (n=24), including 7 in CP-Ⅰ, 5 in CP-Ⅱ and 3 in CP-Ⅲ subgroups. FVID of experimental group was lower than that of control group at 5 and 15 minutes after secretin injection (F=9.742, 13.543, both P<0.05). There were significant differences of FVID between control group and CP-Ⅱ subgroup, as well as between control group and CP-Ⅲ subgroup (both P<0.05). Moreover, significant difference of FVID was found between CP-Ⅰ and CP-Ⅲ subgroup (P<0.05). Although there was no significant difference between other groups (all P>0.05), FVID showed a downward trend with increased worsening degrees of CP. Conclusion S-MRCP can be used to quantify pancreatic exocrine function of cat CP models by detecting FVID changes before and after secretin injection. |
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