| 徐惠,朱建忠,孙向东,赵梦,李传福.乙醇气味刺激食蟹猴的脑fMRI[J].中国医学影像技术,2011,27(10):1963~1966 |
| 乙醇气味刺激食蟹猴的脑fMRI |
| Functional MRI of brain in macaca fascicularis under alcohol scent stimulation |
| 投稿时间：2011-04-29 修订日期：2011-06-28 |
| DOI： |
| 中文关键词: 非人灵长类动物 乙醇 嗅觉 磁共振成像 |
| 英文关键词:Nonhuman primate Alcohol Smell Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 应用3.0T fMRI探讨食蟹猴经乙醇气味刺激引起的脑功能活动。方法 选取健康食蟹猴6只,麻醉后行乙醇气味刺激下的fMRI。采取"静息-刺激-静息"组块设计。刺激组块予乙醇气味刺激,静息组块无气味刺激。BOLD-fMRI扫描128 phase,整个猴脑扫描16层。采用SPM2软件随机效应模式t检验进行组分析。将统计结果覆盖于食蟹猴模板图像上。结果 乙醇气味刺激下,在额叶、颞叶、中央旁小叶、扣带回、豆状核、中央前回分别可以检测到正激活和负激活。结论 海马回钩和眶额回为嗅觉最高级中枢。fMRI可以显示额叶、颞叶的激活。气味刺激引起的中枢反应与中央旁小叶、扣带回、豆状核有密切关系。 |
| 英文摘要: |
| Objective To explore the fMRI changes of brain in macaca fascicularis with alcohol scent stimulation. Methods Six healthy macaca fascicularis were selected and anesthetized. The block design was "rest-stimulation-rest". fMRI under alcohol scent stimulation and resting state were performed, respectively. The animals inhaled air mixed with 95% alcohol in the stimulation period, while inhaled pure air in rest period. BOLD-fMRI sequences and 128 phases scanning were performed, 16 slices axial images of the entire brain and total 2048 images were obtained. Data were analyzed using SPM2. The outcomes were superposed on the template of macaca fascicularis at last. Random effect mode group analysis was applied in estimating and calculating with t-test. Results When alcohol scent stimulation was given, increased or decreased BOLD signals were observed in frontal lobe, temporal lobe, paracentral lobules, cingulate gyri, and lenticular nucleus, and anterior central gyrus, respectively. Conclusion Uncus gyri hippocampi and orbitofrontal are the most advanced center of olfaction. The central reaction induced by scent stimulation had an affinity with paracentral lobule, cingulate gyrus and lenticular nucleus. |
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