| 段星星,陈文娟,朱文晖,何静波,李皓.心力衰竭大鼠左心室非同步化与心肌基质金属蛋白酶-9表达的关系[J].中国医学影像技术,2011,27(4):673~676 |
| 心力衰竭大鼠左心室非同步化与心肌基质金属蛋白酶-9表达的关系 |
| Relationship between the dyssynchrony of left ventricular and the expression matrix metalloproteinase-9 in rats with heart failure |
| 投稿时间：2010-09-29 修订日期：2010-11-10 |
| DOI： |
| 中文关键词: 心肌梗死 心力衰竭 基质金属蛋白酶9 非同步化 |
| 英文关键词:Myocardial infarction Heart failure Matrix metalloproteinase 9 Dyssynchrony |
| 基金项目:湖南省自然科学基金(09JJ6043)。 |
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| 中文摘要: |
| 目的 探讨心力衰竭大鼠左心室非同步化与心肌基质金属蛋白酶-9(MMP-9)表达的关系。 方法 将70只雄性SD大鼠随机分为4组:手术4周组、手术8周组、假手术组及正常组。应用定量组织速度成像(QTVI)评价大鼠左心室非同步运动。用Western Blot法检测各组实验大鼠心肌MMP-9表达。 结果 ①随着时间推移,心功能逐渐下降,手术大鼠左心室非同步指标逐渐延长而假手术组大鼠的变化不明显。②手术4周组和手术8周组大鼠心肌MMP-9的表达较正常组及假手术组明显增加(P<0.01),且手术8周组MMP-9的表达高于手术4周组(P<0.05)。 结论 心力衰竭大鼠左心室非同步化程度与心肌MMP-9表达程度密切相关。 |
| 英文摘要: |
| Objective To explore the relationship between the dyssynchrony of left ventricular and the expression of matrix metalloproteinase-9 (MMP-9) in rats with heart failure. Methods Seventy male SD rats were randomly divided into 4 groups: The 4 weeks after surgery group, the 8 weeks after surgery group, the sham operation group and the control group. The parameters of the rats' left intraventricular dyssynchrony were obtained with quantitative tissue velocity imaging (QTVI), and the myocardial MMP-9 was detected with Western Blot. Results ①As the process of the heart failure, all of the indexes of the dyssynchrony were getting longer and longer in the operation groups, while the changes in the sham operation group was not significant. ②The MMP-9 levels of 4 weeks and 8 weeks after surgery groups increased significantly (P<0.01), and the protein level of 8 weeks after surgery group was higher than that in 4 weeks after surgery group (P<0.05). Conclusion The left ventricular dyssynchrony is closely related to the level of MMP-9 of rats with heart failure. |
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