| 马占龙.MRI评价兔动脉粥样硬化模型[J].中国医学影像技术,2010,26(s1):1~3 |
| MRI评价兔动脉粥样硬化模型 |
| MRI evaluation of carotid artery atherosclerosis in rabbits model |
| 投稿时间：2010-08-10 修订日期：2010-08-30 |
| DOI： |
| 中文关键词: 动脉硬化 磁共振成像 兔 |
| 英文关键词:Arteriosclerosis Magnetic resonance imaging Rabbits |
| 基金项目:江苏省自然科学研究基金(BK2008222)、国家自然科学基金面上项目(81071193)。 |
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| 中文摘要: |
| 目的 探讨1.5T MR仪检测兔颈动脉粥样硬化模型中粥样硬化斑块的形成。 方法 用动脉球囊扩张法损伤兔一侧颈总动脉血管内膜后高脂饲养15周,行MRI及损伤血管的病理学检查。 结果 15周后,MRI表现为损伤血管壁高信号区增厚并管腔狭窄,对应病理学检查显示:血管腔狭窄;损伤侧颈总动脉明显粥样斑块形成,符合动脉粥样硬化特点。MR成像与病理学所测血管壁厚度之间有相关关系(r＝0.953)。 结论 临床应用型1.5T MRI可成功检测兔颈动脉粥样硬化的形成。 |
| 英文摘要: |
| Objective To study 1.5T MR of the carotid artery atherosclerosis in rabbits model. Methods Rabbits were fed with high lipid diet for 15 weeks after carotid arteries were injured by balloons. The formation of atherosclerosis in the injured arteries was observed with MRI. The animals were killed after MRI and the pathologic changes in bilateral carotid arteries were observed. Results MRI showed in high signal in the vessel wall of the injured arteries and the lumen of blood vessel was stenosed after 15 weeks. The pathological study showed that in the end of 15th week, vascular smooth muscle (VSM) were irregularly proliferated, there were formations of atheroscelerosis in the injured arteries and the lumen of the blood vessel stenosed in obviously. Statistical analysis revealed a significant agreement between the MRI and histological findings (r=0.953). Conclusion MR images with a conventional 1.5T MRI system are able to visualize the carotid artery atherosclerotic plaque formation in a rabbit model. |
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