| 刘虎,范国光,徐克,李焕焕,邵建.低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动[J].中国医学影像技术,2010,26(9):1659~1662 |
| 低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动 |
| Amplitude of low-frequency fluctuation study of resting-state functional MRI in schizophrenia |
| 投稿时间：2010-05-14 修订日期：2010-06-02 |
| DOI： |
| 中文关键词: 精神分裂症 磁共振成像 低频振幅 |
| 英文关键词:Schizophrenia Magnetic resonance imaging Amplitude of low-frequency fluctuation |
| 基金项目: |
|
| 摘要点击次数: 2373 |
| 全文下载次数: 1051 |
| 中文摘要: |
| 目的 采用低频振幅(ALFF)方法评价精神分裂症患者静息状态下脑功能活动。 方法 对13例符合精神分裂症诊断标准的患者(精神分裂症组)及18名健康志愿者(正常对照组)行静息态脑fMR扫描,精神分裂症患者和正常对照者的ALFF差异用双样本t检验。 结果 与正常对照组相比,精神分裂症组静息状态下右侧胼胝体压部、右侧枕叶、左侧小脑后叶、左侧额上回和左侧楔前叶脑区ALFF增高,差异有统计学意义(P<0.001,未校正);双侧中央后回和左侧楔前叶脑区ALFF降低,差异有统计学意义(P<0.001,未校正)。 结论 精神分裂症患者静息状态下脑功能存在异常,ALFF有助于对精神分裂症患者静息状态脑功能的理解。 |
| 英文摘要: |
| Objective To evaluate brain activity in resting-state of schizophrenia patients with amplitude of low-frequency fluctuation (ALFF). Methods Thirteen schizophrenia patients and 18 healthy controls underwent functional MR examination in resting-state, and the difference of ALFF between patients and controls was analyzed with two-sample t test. Results Compared with controls, significantly increasing areas of ALFF in resting-state of schizophrenia included right splenium of corpus callosum, right occipital lobe, left posterior lobe of cerebellum, left superior frontal gyrus and left precuneus (P<0.001, uncorrected), and the decreasing areas included bilateral postcentral gyrus and left precuneus (P<0.001, uncorrected). Conclusion The resting-state fMRI study suggests abnormal brain activity of schizophrenia might exist in resting state, and ALFF might contribute to the understanding of schizophrenia patients' brain function in resting state. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
