| 林琳,郑容,王奕斌,耿建华,吴宁.PET/CT显像勾画放疗靶区的边界阈值的体外模型实验[J].中国医学影像技术,2010,26(8):1421~1423 |
| PET/CT显像勾画放疗靶区的边界阈值的体外模型实验 |
| Phantom research of threshold segmentation for PET/CT target volume delineation in radiation treatment planning |
| 投稿时间：2010-03-20 修订日期：2010-05-19 |
| DOI： |
| 中文关键词: 18F 氟脱氧葡萄糖 正电子发射型体层摄影术 阈值 放射疗法 |
| 英文关键词:Fluorodeoxyglucose F18 Positron-emission tomography Threshold Radiotherapy |
| 基金项目: |
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| 摘要点击次数: 3478 |
| 全文下载次数: 982 |
| 中文摘要: |
| 目的 通过模型实验研究PET图像中热球模型的边界阈值,为放疗计划中生物学靶区的勾画奠定方法学基础。方法 建立容积0.5~16.0 ml、靶本底比值分别为164.13 ∶ 1、32.96 ∶ 1、12.69 ∶ 1及热球零本底的热球模型,观察热球边界阈值及其与体积、靶本底比值、采集模式的关系。结果 体积≥2.0 ml的热球的边界阈值位于36.80%~43.70%的区间(平均39.59%)。而体积<2.0 ml的热球的边界阈值位于39.30%~50.90%的区间(平均45.98%)。体积≥2.0 ml的四种体积热球的平均边界阈值间差异均无统计学意义(P均＞0.05);而体积<2.0 ml的热球的边界阈值却随体积的增大而减小(P=0.015)。靶本底比值大于12.69 ∶ 1时,热球的边界阈值不受靶本底比值变化的影响(P均＞0.05)。相同采集时间内2D和3D采集模式对边界阈值的影响差异无统计学意义(P=0.164)。结论 体积≥2.0 ml的热球,边界阈值不随体积的变化而发生显著变化,推荐40%作为边界阈值。 |
| 英文摘要: |
| Objective To explore the threshold in the phantom with hot spheres, and to get the method to define a biological target volume contour with integrated PET/CT. Methods Spheres with volumes ranging from 0.5 to 16.0 ml and target/background activity concentration (T/N) ratio of 164.13 ∶ 1, 32.96 ∶ 1 and 12.69 ∶ 1, as well as those without background were established. The relationship between the threshold and the target volume, target/background activity concentration ratio and imaging mode was observed. Results The threshold of the spheres with the volumes ≥2.0 ml ranged from 36.80% to 43.70% (average 39.59%). The threshold of the spheres with the volumes <2.0 ml ranged from 39.30% to 50.90% (average 45.98%). There was no significant difference among the average thresholds of spheres with volumes ≥2.0 ml (P＞0.05). The thresholds of spheres with the volumes <2.0 ml significantly decreased as the volumes increased (P=0.015). When the T/N ratio＞12.69 ∶ 1, the thresholds of spheres were not obviously affected by the change of the T/N ratio (P＞0.05). There was no significant difference of the threshold value between 2D and 3D imaging mode in the same time. Conclusion The thresholds of the spheres with the volumes ≥2.0 ml were not changed obviously as the volumes increased, so the threshold 40% is recommended as the contour threshold. |
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