| 马聪,张礼荣,尉传社,王冬青,王德航.3.0T MR半自动软件软骨体积定量测量的可重复性及准确性[J].中国医学影像技术,2010,26(4):760~763 |
| 3.0T MR半自动软件软骨体积定量测量的可重复性及准确性 |
| Repeatability and accuracy of quantitative knee cartilage volume measurement using semi-automated software at 3.0T MR |
| 投稿时间：2009-10-31 修订日期：2010-01-27 |
| DOI： |
| 中文关键词: 磁共振成像 膝关节 软骨 体积 OsiriX |
| 英文关键词:Magnetic resonance imaging Knee joint Cartilage Volume OsiriX |
| 基金项目:江苏大学临床科研基金(JNY20080032)、镇江市科技计划项目(SH2006029)。 |
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| 中文摘要: |
| 目的 评估在3.0T MR上使用半自动软件OsiriX测量膝关节软骨体积的可重复性及准确性。 方法 在3.0T MR上使用MR轴位水激发3D-FLASH序列对30名健康受试者的右膝关节进行重复扫描。全部图像由3名观察者分别使用开放源软件OsiriX进行软骨的半自动分割及随机工作站进行人工分割,计算软骨体积,比较两种方法测量软骨体积所需时间、可重复性及测量结果。 结果 ①OsiriX软件分割比人工分割节省50%以上时间;②OsiriX软件分割及人工分割的观察者间可重复性误差分别为4.88%和9.82%,高年资观察者内部可重复性误差分别为0.77%和1.29%,个体内部可重复性误差范围分别为0.14%~1.11%和0.52%~1.61%。前者各项可重复性误差均低于后者(P＜0.05);③OsiriX软件分割的系统误差为(－3.80±3.93)%,随机配对误差为(4.68±2.70)%,差异无统计学意义(t=0.92,P=0.36)。 结论 与人工分割相比,OsiriX半自动分割测量软骨体积具有省时、观察者间及观察者内可重复性高、有相对固定标准等明显优势,可用于临床及多中心大样本量研究。 |
| 英文摘要: |
| Objective To evaluate the repeatability and accuracy of semi-automated software OsiriX in the assessment of cartilage volume in normal knees on 3.0T MR. Methods Thirty right knees of healthy subjects were scanned twice with 3.0T MR using 3D-FLASH sequence with selective water excitation. Cartilage volume of the patellar compartment was determined with a validated open-source software OsiriX and manual segmentation separately by 3 observers using MRI data sets. After calculating the cartilage volumes, the segmentation processing times, the repeatability and volume results were compared between two segmentations. Results ①Compared with the manual segmentation, a time saving of at least 50% for cartilage volume measurement was achieved with OsiriX software segmentation. ②The interobserver repeatability error was 4.88% and 9.82% with OsiriX software segmentation and manual segmentation, respectively; the intraobserver repeatability error of high experienced observer was 0.77% and 1.29%, the interindividual repeatability range were 0.14%—1.11% and 0.52%—1.61%, respectively. The repeatability error of OsiriX software segmentaion was proved to be significantly smaller than manual segmentation (P＜0.05). ③System difference between results obtained with OsiriX software measurement and manual measurement was (－3.80±3.93)% and absolute pairwise difference was (4.68±2.70)%. There was no statistical difference between the volume results measured using two techniques (t=0.92, P=0.36). Conclusion Compared to manual segmentation, cartilage volume measurement with OsiriX semi-automated segmentation is faster and has higher inter- and intraobserver repeatability with relatively fixed standard. This technique may therefore be used for clinical and multi-center trials of large sample. |
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