| 刘侃,周纯武,欧阳汉,罗德红.3.0T MR扩散加权成像鉴别鼻咽癌患者颈部转移淋巴结[J].中国医学影像技术,2010,26(3):468~471 |
| 3.0T MR扩散加权成像鉴别鼻咽癌患者颈部转移淋巴结 |
| Differential diagnosis of metastatic cervical lymph nodes in nasopharyngeal carcinoma patients with 3.0T MR diffusion weighted imaging |
| 投稿时间：2009-10-13 修订日期：2009-12-01 |
| DOI： |
| 中文关键词: 淋巴结 肿瘤转移 扩散加权成像 磁共振成像 |
| 英文关键词:Lymph nodes Neoplasm metastasis Diffusion weighted imaging Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨3.0T MR颈部扩散加权成像(DWI)区分鼻咽癌患者颈部淋巴结良恶性的价值及适宜的b值。方法 采用GE 3.0T MR及颈部8通道相控阵线圈对50例鼻咽癌患者及20名志愿者行单次激发自旋回波平面回波DWI,分别使用4组b值(600、800、1000、1200 s/mm2)扫描,将鼻咽癌组中判断为转移的淋巴结与志愿者组的淋巴结ADC值分组进行比较。结果 b=600、800、1000、1200 s/mm2时,鼻咽癌转移淋巴结ADC值(×10－3 mm2/s)分别为0.808±0.112、0.769±0.098、0.732±0.095、0.696±0.083;正常对照组良性淋巴结ADC值(×10－3 mm2/s)分别为0.993±0.172、0.967±0.165、0.903±0.157、0.855±0.122。转移淋巴结ADC值明显低于相应良性淋巴结(P<0.05)。当b=800 s/mm2,ROC曲线上ADC诊断阈值取0.873×10－3 mm2/s时,鉴别诊断鼻咽癌转移淋巴结与良性淋巴结的敏感度为88.41%,特异度为69.43%,准确率为75.22％,既能兼顾良好的图像质量又能得到较准确的测量数值。结论 作为一种快速、灵敏的MR成像技术,DWI有助于区分鼻咽癌患者颈部淋巴结的良恶性。 |
| 英文摘要: |
| Objective To explore the capability of diffusion weighed imaging (DWI) in differentiating malignant cervical lymph nodes from benign ones in nasopharyngeal carcinoma (NPC) patients, and to assess the appropriate b value in 3.0T MR DWI. Methods Conventional MR and DWI scan were performed in 50 patients with histopathologically proven NPC and 20 healthy volunteers with GE 3.0T MR scanner, and neurovascular array 8 channels head and neck unite coil. DWI was performed with single shot spin-echo echo-planar imaging (SE-EPI) sequence at 4 different b values (600, 800, 1000,1200 s/mm2). The apparent diffusion coefficient (ADC) values between metastatic lymph nodes of NPC patients and benign nodes of volunteers were compared. Results The mean ADC value (×10－3 mm2/s) of metastatic cervical lymph nodes of NPC at different b value (600, 800, 1000, 1200 s/mm2) was 0.808±0.112, 0.769±0.098, 0.732±0.095 and 0.696±0.083, respectively; the mean ADC value (×10－3 mm2/s) of lymph nodes of volunteers was 0.993±0.172, 0.967±0.165, 0.903±0.157 and 0.855±0.122, respectively (P<0.05). When b value was 800 s/mm2, and ROC cut-off point was 0.873×10－3 mm2/s, the diagnostic sensitivity, specificity and accuracy was 88.41%, 69.43%, and 75.22%, respectively. Both the satisfying images and the accurate measurement were acquired. Conclusion As a rapid and sensitive new MR technique, DWI can offer help in discriminating benign and malignant cervical lymph nodes in NPC patients. |
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