| 秦玲娣,周滟,陈俊,朱炯,陶静,钱黎俊,许建荣.难治性抑郁症患者静息状态默认网络的改变[J].中国医学影像技术,2009,25(12):2182~2185 |
| 难治性抑郁症患者静息状态默认网络的改变 |
| Changes of resting-state default-mode network functional connectivity in patients with treatment-resistant depression |
| 投稿时间：2009-05-25 修订日期：2009-08-22 |
| DOI： |
| 中文关键词: 抑郁症 默认网络 功能连接 扣带回后部 |
| 英文关键词:Depression Default-mode network Functional connectivity Posterior cingulate cortex |
| 基金项目:上海交通大学医学院重点学科项目、上海市重点学科建设项目(S30203)。 |
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| 中文摘要: |
| 目的 探索难治性抑郁症(TRD)患者脑静息状态默认网络与正常对照组间的差异。方法 10例TRD患者和12名对照者接受440 s的静息脑功能扫描。运用功能连接分析得出个体的静息状态默认网络并进行组间比较。结果 与对照组比较,TRD组双侧颞中回、直回、楔前回、左侧眶回、右侧顶下小叶与后扣带回的连接功能减弱。结论 TRD患者的静息默认网络连接中多个脑区活动减弱,可能导致患者自我控制和情感行为功能异常。 |
| 英文摘要: |
| Objective To explore the difference of resting-state default-mode network functional connectivity in patients with treatment-resistant depression (TRD) and in healthy subjects. Methods Ten patients with TRD and 12 healthy control subjects underwent 440 s fMRI scans while resting quietly. Functional connectivity analysis was used to isolate the default mode network in each subject. Group maps of the default-mode network were generated and compared between the two groups. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on network functional connectivity. Results Functional connectivity of both side of middle temporal gyrus, rectal gyrus, precuneus gray matter, left orbital gyrus, right inferior parietal lobule, and post cingulate gyrus in TRD group weakened compared with that of the control subjects. Conclusion There are resting default network connection weakening in multiple brain areas in TRD patients, which may lead to self-control and emotional behavior abnormal in patients. |
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