| 王润文,周高峰,彭仁罗,王小宜,刘凡,贾高志,周勉,聂吉林.颅内肿瘤大剂量Gd-DTPA MR灌注成像的临床应用及安全性[J].中国医学影像技术,2008,24(4):611~613 |
| 颅内肿瘤大剂量Gd-DTPA MR灌注成像的临床应用及安全性 |
| Application and safty of perfusion-weighted MR imaging with large dose of Gd-DTPA in the diagnosis of intracranial tumors |
| 投稿时间：2007-11-28 修订日期：2008-03-24 |
| DOI： |
| 中文关键词: 脑肿瘤 磁共振成像 灌注加权成像 对比剂 |
| 英文关键词:Brain neoplasms Magnetic resonance imaging Perfusion weighted imaging Contrast media |
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| 中文摘要: |
| 目的 探讨颅内肿瘤大剂量Gd-DTPA MR灌注成像的应用价值及安全性。 方法 收集经病理证实的颅内肿瘤36例,其中低级别胶质瘤(Ⅰ~Ⅱ级)15例,高级别胶质瘤(Ⅲ~Ⅳ级)12例,脑膜瘤7例,胆脂瘤1例,脉络丛乳头状瘤1例,使用FID-EPI序列行Gd-DTPA灌注成像。在脑血流容积的伪彩色图像上测得肿瘤的rCBV值,并对各组肿瘤的rCBV值进行统计学t检验;记录注药后患者的表现及不良反应,评价大剂量Gd-DTPA灌注的安全性。结果 低级别胶质瘤与高级别胶质瘤的rCBV值,低级别胶质瘤与脑膜瘤的rCBV值比较有统计学意义(P<0.05),而高级别胶质瘤与脑膜瘤的rCBV值比较没有统计学意义(P>0.05)。1例脉络丛乳头状瘤的rCBV值为9.15,表现为高灌注;1例胆脂瘤的rCBV值为0.09,表现为低灌注;36例灌注患者未见药物过敏反应。结论 大剂量Gd-DTPA的MR灌注成像有助于脑胶质瘤的分级及与其他颅内肿瘤的鉴别诊断,临床应用的安全性良好。 |
| 英文摘要: |
| Objective To study the value and safety of perfusion-weighted MR imaging with large dose of Gd-DTPA in the diagnosis of intracranial tumors. Methods MR PWI with FID-EPI sequence was performed in 36 patients with intracranial tumors, including 15 cases of low-grade (grade Ⅰ-Ⅱ) glioma, 12 cases with high-grade (grade Ⅲ-Ⅳ) glioma, 7 cases with meningioma, one case with cholesteatoma and one case with choroid plexus papilloma. The tumors' rCBV were measured on the pseudo-color images of CBV, which were undertook t test. The safty of PWI with large dose of Gd-DTPA was evaluated by writing down the appearances of patients and adverse reactions of Gd-DTPA. Results The difference of rCBV between low-grade gliomas and high-grade gliomas, meningiomas were statistically significant (P<0.05). However, the rCBV between high-grade glimoas and meningiomas showed no statistic difference (P>0.05). One choroid plexus papilloma and one cholesteatoma showed hypertransfusion (9.15) and hypoperfusion (0.09) respectively. No allergic reactions of drug occurred in 36 patients. Conclusion PWI with large dose of Gd-DTPA is helpful in grading gliomas and differential diagnosis of intracranial tumors, which is safe in clinic application. |
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