| 计晓娟,李锦青,邹建中,王智彪.超声造影剂联合高强度聚焦超声损伤兔肝VX2移植瘤的可行性研究[J].中国医学影像技术,2006,22(7):1006~1008 |
| 超声造影剂联合高强度聚焦超声损伤兔肝VX2移植瘤的可行性研究 |
| Feasibility study of high intensity focused ultrasound combining with ultrasound contrast agent to damage hepatic VX2 tumors in rabbits |
| 投稿时间：2006-03-22 修订日期：2006-05-18 |
| DOI： |
| 中文关键词: 兔/动物模型 肝肿瘤 高强度聚焦超声 超声造影剂 |
| 英文关键词:Rabbit/animal model Hepatic neoplasms High intensity focused ultrasound Ultrasound contrast agent |
| 基金项目:本研究受国家教育部创新团队发展计划(教技函[2005]33号)、国家自然科学基金(30325027)及重庆市科委自然科学基金重点项目(渝科发计字[2004]47号)资助。 |
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| 中文摘要: |
| 目的 研究超声造影剂作为一种增效剂,增强高强度聚焦超声的生物学效应,损伤兔肝VX2移植瘤的可行性。方法 30只荷瘤兔随机分为二组,单纯高强度聚焦超声辐照组和联合辐照组,超声造影剂剂量为0.05 ml/kg。结果 联合辐照组的辐照时间明显缩短(P＜0.05),损伤肿瘤体积大大增加(P＜0.01),损伤效率高于单纯高强度聚焦超声辐照组(P＜0.01)。结论 超声造影剂可以提高高强度聚焦超声损伤效率,靶区组织的声学特性、组织结构或者功能状态可以影响高强度聚焦超声治疗剂量。 |
| 英文摘要: |
| Objective To assess the feasibility of ultrasound microbubble contrast agent combining with high intensity focused ultrasound to treat hepatic VX2 tumors in rabbits. Methods Thirty rabbits borne VX2 tumors were randomly averagely assigned into two groups. One group accepted purely high intensity focused ultrasound (HIFU) irradiation, and the other group accepted treatment by HIFU combined with ultrasound contrast agent. Results Duration of purely high intensity focused ultrasound therapy tumors was much longer than that of enhanced high intensity focused ultrasound group, but smaller damaged volumes. Conclusion It was feasible to enhance HIFU therapy with microbubble contrast agent. The energy efficiency factor (EEF) can be changed and decreased by actively changing tissue structure and its function. |
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