| 于春水,李坤成,朱朝喆,秦文,孙红,陈彪.胼胝体扩散指标对鉴别复发性视神经脊髓炎和复发好转型多发性硬化的价值[J].中国医学影像技术,2006,22(7):967~970 |
| 胼胝体扩散指标对鉴别复发性视神经脊髓炎和复发好转型多发性硬化的价值 |
| Differentiate relapsing neuromyelitis optica from relapsing-remitting multiple sclerosis using diffusion indices of the corpus callosum |
| 投稿时间：2006-01-22 修订日期：2006-05-10 |
| DOI： |
| 中文关键词: 视神经脊髓炎 多发性硬化 扩散张量成像 鉴别诊断 |
| 英文关键词:Neuromyelitis optica Multiple sclerosis Diffusion tensor imaging Differential diagnosis |
| 基金项目:本课题为北京市自然科学基金(NO.7042026)和北京市优秀人才培养专项经费资助项目。 |
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| 中文摘要: |
| 目的 研究胼胝体扩散指标对鉴别复发性视神经脊髓炎(RNMO)和复发好转型多发性硬化(RRMS)的价值。方法 对110例复发性脱髓鞘病患者行常规MRI和DTI检查,从中选择诊断明确的RNMO患者26例和RRMS患者31例进行分析。以正中矢状面分数各向异性(FA)图上的胼胝体作为感兴趣区(ROI),分别测量该ROI的平均扩散率(MD)、FA、最大本征值(λ1)和横向本征值(λ2-3),并将其作为分类指标,观察这些指标对鉴别RNMO和RRMS的效果。结果 RNMO患者胼胝体的MD、FA、λ1和λ2-3 与RRMS患者明显不同 (P＜0.001)。通过选取恰当的分类阈值(MD=9.31×10-4 mm2/s, FA=0.685; λ2-3 =4.98×10-4 mm2/s),利用胼胝体的MD、FA和λ2-3 可将这两组患者区分开, 分类准确性分别达到92.98%,89.47%和91.23%。结论 胼胝体扩散指标能够较为准确地鉴别RNMO和RRMS。 |
| 英文摘要: |
| Objective To investigate whether diffusion indices of the corpus callosum can differentiate relapsing neuromyelitis optica (RNMO) from relapsing-remitting multiple sclerosis (RRMS). Methods Conventional and diffusion tensor imaging (DTI) were performed in 110 patients with recurrent demyelinating diseases. From them, 31 patients were definitely diagnosed as RRMS and 26 patients as RNMO. The mean diffusivity (MD), fractional anisotropy (FA), primary eigenvalue (λ1), and transverse eigenvalues (λ2-3) from the region of the corpus callosum on the mid-sagittal FA image were measured and taken as the discriminative indices. The performance of these indices for differentiating RNMO from RRMS was observed. Results The average MD, FA, λ1 and λ2-3 of the corpus callosum of RRMS patients were significantly different from those of RNMO patients (P＜0.001). RNMO patients could be discriminated from RRMS by choosing appropriate cut-offs (MD=9.31×10-4 mm2/s, FA=0.685; λ2-3 =4.98×10-4 mm2/s) of the corpus callosum. The accuracy for this differential diagnosis was 92.98% for MD, 89.47% for FA and 91.23% for λ2-3, respectively. Conclusion Diffusion indices of the corpus callosum can differentiate RNMO from RRMS. |
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