| 肖亮,徐克,于世平,王少雷,邵海波,卢涛,王强,郭敏.经皮经腔内膜剥脱法主动脉夹层模型的制备及影像学评价[J].中国医学影像技术,2006,22(4):532~534 |
| 经皮经腔内膜剥脱法主动脉夹层模型的制备及影像学评价 |
| Percutaneous transluminal preparation of aortic dissection model and imaging evaluation |
| 投稿时间：2005-09-07 修订日期：2006-01-06 |
| DOI： |
| 中文关键词: 主动脉夹层 动物模型 腔内操作 主动脉造影 体层摄影术,X线计算机 |
| 英文关键词:Aortic dissection Animal model Transluminal operation Aortography Tomography, X-ray computed |
| 基金项目:卫生部科技基金资助项目(WZK-2000-1-16)。 |
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| 中文摘要: |
| 目的 探索经皮经腔内膜剥脱法制备主动脉夹层动物模型的可行性及主动脉造影、CT影像的评价。方法 15条健康杂种犬,分别采用自制金属倒钩或带针尖导管等器械行经皮经主动脉腔内膜损伤、剥脱法制备主动脉夹层模型,随后进行主动脉造影及CT增强扫描,观察动物模型制备的成功率、预后,获取标本,分析图像。结果 15条犬中,形成主动脉夹层模型4例,技术成功率26.7％(4/15),其余11条犬均发生主动脉破裂、穿孔、死亡。主动脉造影发现2例主动脉夹层,CT扫描发现3例主动脉夹层。结论 经皮经腔内膜剥脱法制备主动脉夹层的难度大,成功率偏低,需进一步积累经验。 |
| 英文摘要: |
| Objective To explore the percutaneous transluminal technique of preparation for aortic dissection animal model and evaluate aortography, CT images of animal model. Methods Fifteen dogs were prepared for aortic dissection, 10 by using aortic transluminal self-made metal hook and 5 by using needle-tip catheter respectively. The following operative steps were employed: ① disassociating femoral and humerus artery and placing sheath; ② abdominal aortic angiography through humerus artery; ③ transporting 12 F sheath loading self-made metal hook or needle-tip catheter into thoracic aorta through femoral artery; ④ under X-ray monitoring, metal hook cut the inner wall of the descending aorta, then with 5F catheter and guide wire, searched for the intimal injury spot, and broadened the tear of intimal to evoke the aortic dissection; ⑤ under X-ray monitoring, the needle-tip catheter was slipped through femoral artery to descending aorta, and inserted into the aortic wall. The diluted contrast agent mixed with elastase and heparin was infused so that affected by both the biological injury by the elastase and physical laceration by the pressure of the infused liquid the aortic dissection will appear. After transluminal operation, we got aortography and CT scanning images, observed the prognosis of the animal model and finally acquired aortic specimen and analyzed images. Results Among the 15 dogs for the experiment, 4 aortic dissections appeared by the preparation of transluminal metal hook and the other 11 cases with aortic rupture, perforation, or death with the success rate of 26.7% (4/15). The aortography showed 2 cases of aortic dissection with narrowed true lumen and slower blood flow in the false lumen and no observed secondary tear. CT scanning displayed 3 cases of aortic dissection with raised intimal, double-barrel, no obvious expansion of the lumen and secondary tear. The specimen observation suggested: 4 cases of aortic dissection with the ranges to 1.0 cm, 3.0 cm, 9.5 cm and 13.5 cm respectively, the wall injury reaching into the media and the injure size up to 0.5 cm and 1.5 cm and one cycle loss. Conclusion The operation of interventional transluminal preparing aortic dissection was difficult and its success rate was low, the experience of it must be increased by operating. |
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