| 任燕双,张云亭,刘松龄.大鼠短暂性脑缺血发作后短T1信号产生的病理基础[J].中国医学影像技术,2006,22(3):337~340 |
| 大鼠短暂性脑缺血发作后短T1信号产生的病理基础 |
| Pathological basis of high signal intensity on T1 weighted imaging after transient ischemic attacks in rats |
| 投稿时间：2005-10-19 修订日期：2005-12-10 |
| DOI： |
| 中文关键词: 动物,实验 磁共振成像 脑缺血发作,短暂性 |
| 英文关键词:Animals, laboratory Magnetic resonance imaging Ischemic attack, transient |
| 基金项目: |
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| 中文摘要: |
| 目的 揭示短暂性脑缺血发作后短T1信号产生的病理基础。方法 将20只雄性Wistar大鼠随机分为实验组(n=13)和对照组(n=7),采用Zea-Longa法制备15 min MCA闭塞-再通时间的大鼠模型,分别于第3、5、7、14天4个时间点观察短T1信号出现的时间、部位,采用HE染色、Perls染色及电镜检查观察短T1信号部位的病理变化。结果 对照组中无短T1信号出现,实验组中7只大鼠模型于第14天时出现短T1信号,其中4只出现在皮质区,2只出现在皮质区和基底节区,1只仅于基底节区出现。皮质区短T1信号主要与出血有关;基底节区短T1信号主要与吞噬脂肪的巨噬细胞的脂质沉积有关。结论 TIA后短T1高信号出现的部位不同,其产生的病理基础不同。 |
| 英文摘要: |
| Objective To vertify the pathological basis of the short T1 signal intensity after transient ischemic attacks (TIA) in rat models. Methods Twenty male Wistar rats were used for the rat models of middle cerebral artery occlusion (MCAO) according to the intraluminal filament technique modified by Zea-Longa. They were divided into two groups randomly, experimental group (n=13) and control group (n=7). Follow-up MR examination was applied to observe the time and the position of short T1 signal occurred. HE staining, Perls staining and electrimicroscopic examinations were applied to observe the pathological changes in the position of short T1 signal appeared. Results In control group (n=7), no short T1 signal was observed in bilateral cerebral hemispheres. In experimental group (n=13), short T1 signal was observed in 7 rats at the 14th day. Four of them occurred in cortical area, 2 of them occurred in both cortical area and basal ganglia, only 1 of them appeared in basal ganglia. Short T1 signal in cortical region was mainly related with hemorrhage, short T1 signal in basal ganglia was induced by lipid-laden macrophages. Conclusion The pathological basis of short T1 signal was different in different position in brain tissue after TIA. |
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