| 张瑞英,沈景霞,孙艺红,黄永麟.超声评价福辛普利和依贝沙坦对心肌梗死大
鼠心脏功能的影响[J].中国医学影像技术,2002,18(10):980~982 |
| 超声评价福辛普利和依贝沙坦对心肌梗死大
鼠心脏功能的影响 |
| Effect of Fosinopril and Irbesartan on Rats with Myocardial Infarction Assessed by Echocardiography and Hemodynamics |
| 投稿时间：2002-02-10 |
| DOI： |
| 中文关键词: 心肌梗死 心室重构 血管紧张素 超声心动图 |
| 英文关键词:Myocardial infarction Ventricular remodeling Angiotensin Echocardiography |
| 基金项目: |
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| 中文摘要: |
| 目的 本研究主要应用高频多普勒超声对比观察福辛普利和依贝沙坦对心肌梗死(MI)后大鼠心脏结构和心脏功能的影响。方法 通过结扎冠状
动脉左前降支诱导大鼠MI,心肌梗死后24h将MI大鼠随机分为:①安慰剂组;②福
辛普利组;③依贝沙坦组;④假手术组。分别于2周和6周时检查以下指标:①左室
舒张末期内径(LVDd),短轴缩短率(FS),射血分数(EF),后壁(PW)增厚率,E/A比
值,及E峰减速度;②平均动脉压,左室舒张末压;③心室重量/体重;心肌梗死面积
。结果 安慰剂组与假手术组相比,左室舒张末压和心室重量/体重、LVD
d均明显增加;福辛普利和依贝沙坦可使动脉压下降,并有效地降低了左室舒张末压和心室重量/体重及抑制LVDd增加。MI后FS、EF及PW增厚率明显降低、E/A及E峰减速度明显升高,福辛普利和依贝沙
坦能明显改善这些异常。结论 多普勒超声结果表明依贝沙坦和福辛普利
一样能在有效地防止MI后心肌肥大、改善血流动力学异常的同时,明显地防止心室扩张,改善
心脏的收缩和舒张功能。 |
| 英文摘要: |
| Objective To compar
e the effects of Fosinopril and Irbesartan on left ventricular geometry and function after myocard
ial infarction(MI) in the rats by Doppler echocardiography. Methods We induced M
I by ligating the left anterior descending coronary artery in the rats.Twenty-f
our hours after coronary ligation,rats were randomly divided into four groups.① MI-placebo; ② MI-Fosinopril; ③ MI-Irbesartan; ④ sham ligation.At two weeks and six weeks after MI,we examined:①
left ventricular dimension end diastole(LVDd),fractional shortening(FS),ejection fraction(EF),posteriol wall thickening,E-wave/A-wave velocity ratio and E-wave deceleration by echocardiography;② mean blood pressure,left ventricular end-diastolic pressure (LVEDP);③ ventricular weight/body weight ratio (HW/BW) and MI size. Results Placebo-treated infarcted rats developed
significant increase in LVEDP,HW/BW,MI and LVDd compared with sham ligation control.Fosinopril
and Irbesartan limited the increase,and decreased mean blood pressure.Placeb
o-treated infarcted rats compared with sham ligation,FS,EF and PW thicking sign
ificantly decreased,E/A and E-wave deceleration increased.Fosinopril and Irbes
artan improved them equally. Conclusion Doppler echocardiograph
y showed that Fosinopril and Irbesartan equally improved systolic and diastolic function and pre
vented the ventricular dilatation.They also limited myocardial hypertrophy and impr
oved hemodynamics. |
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