| 陈亚岩,黄慧,王可,魏英妮,廖佳音,李胜利.孕中晚期产前超声评估外侧裂形态筛查胎儿大脑皮质发育异常[J].中国医学影像技术,2025,41(6):861~865 |
| 孕中晚期产前超声评估外侧裂形态筛查胎儿大脑皮质发育异常 |
| Prenatal ultrasound evaluation on morphology of Sylvian fissure during the second and third trimesters for screening fetal abnormal cerebral cortical development |
| 投稿时间：2024-11-23 修订日期：2025-03-10 |
| DOI：10.13929/j.issn.1003-3289.2025.06.002 |
| 中文关键词: 胎儿 超声检查,产前 大脑皮质 外侧裂 |
| 英文关键词:fetus ultrasonography, prenatal cerebral cortex Sylvian fissure |
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| 中文摘要: |
| 目的 观察孕中晚期产前超声评估外侧裂(SF)形态对于筛查胎儿大脑皮质发育异常的价值。方法 回顾性纳入876胎孕中晚期胎儿,基于产前超声评估SF形态是否正常,观察有无大脑皮质及其他结构发育异常;之后定期复查产前超声,随访妊娠结局及出生后生长发育情况。结果 876胎中,861胎(861/876,98.29%)SF形态正常;11胎(11/876,1.26%)SF发育迟缓(SF形态正常,但与孕周不符)、4胎(4/876,0.46%)SF形态异常,均合并大脑皮层发育异常和/或颅内外结构畸形,随访显示其中4胎SF形态与孕周相符、4胎SF形态仍与孕周不符、2胎SF形态仍异常。上述15胎中,6胎顺利出生且随访至10~15月龄均发育良好、4胎引产;其余5胎中,3胎SF发育迟缓、1胎SF形态异常,均合并其他严重畸形,1胎SF形态异常,均未接受超声复查而予引产或失访。结论 孕中晚期产前超声评估SF形态对筛查胎儿大脑皮层发育异常具有重要临床价值。 |
| 英文摘要: |
| Objective To observe the value of prenatal ultrasound evaluation on morphology of Sylvian fissure (SF) during the second and third trimesters for screening fetal abnormal cerebral cortical development. Methods Totally 876 fetuses in the second and third trimesters were retrospectively included. Prenatal ultrasound was performed to observe the morphology of fetal SF and whether there was complicated abnormalities of the development of cerebral cortical and other structures. Then prenatal ultrasound was regularly reexamined, and the pregnancy outcome, while the growth and development of newborns were followed up. Results Among 876 fetuses, normal SF morphology was observed in 861 fetuses (861/876, 98.29%), while 11 fetuses (11/876, 1.26%) had delayed SF development (normal SF morphology but inconsistent with gestational week) and 4 fetuses (4/876, 0.46%) had abnormal SF morphology, all complicated with abnormal cerebral cortical development and/or intracranial and extracranial structural malformations, and reexamination of prenatal ultrasound showed that SF morphology was consistent with the gestational week in 4 fetuses, SF morphology still did not match the gestational week in 4 fetuses, and SF morphology was still abnormal in 2 fetuses. Among these 15 fetuses, 6 were successfully born and grew well after followed up until 10—15 months, 4 were induced labor, while the rest 4 (3 with delayed SF development and 1 with abnormal SF morphology) complicated with other severe malformations and 1 with abnormal SF morphology were induced labor or lost to follow-up, hence not undergoing ultrasound re-examination. Conclusion Prenatal ultrasound evaluation on SF morphology during the second and third trimesters had important value for screening fetal abnormal cerebral cortical development. |
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