| 李芳.彩色多普勒超声评价糖尿病肾病患者肾内动脉阻力指数与腹主动脉内中膜厚度相关关系[J].中国医学影像技术,2020,36(5): |
| 彩色多普勒超声评价糖尿病肾病患者肾内动脉阻力指数与腹主动脉内中膜厚度相关关系 |
| Evaluation of intra-renal arterial resistance index and its correlation with aortic intima-media thickness in type 2 diabetic nephropathy by color Doppler ultrasonography |
| 投稿时间：2019-10-14 修订日期：2020-05-17 |
| DOI： |
| 中文关键词: 糖尿病肾病 腹主动脉 内-中膜厚度 肾内动脉 彩色多普勒超声 |
| 英文关键词:Diabetic nephropathies Abdominal aorta Intima-media thickness Intra-renal arterial Color Doppler ultrasonography |
| 基金项目:空 |
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| 中文摘要: |
| 目的：应用彩色多普勒超声技术评价糖尿病肾病患者肾内动脉阻力指数（RI）与腹主动脉内-中膜厚度(A-IMT）的相关关系。方法：选取93例2型糖尿病肾病患者，根据肾小球滤过率（GFR）将其分为三组：GFR≥90 ml·min-1·（1.73 m2）-1为B组(33例)，60 ml·min-1·（1.73 m2）-1≤GFR＜90 ml·min-1·（1.73 m2）-1为C组（31例），GFR＜60 ml·min-1·（1.73 m2）-1为D组(29例)，同时选取35名健康自愿者为A组。应用彩色多普勒超声技术获得肾内动脉阻力指数和腹主动脉内-中膜厚度。结果：各组RI及A-IMT比较：B、C、D组高于A组(P均<0.05)，C、D组高于B组(P均<0.05)，D组高于C组(P均<0.05)。RI与A-IMT（r =0.90，P=0.00）、HbA1C（r=0.58，P=0.00）、Glu（r=0.66，P=0.00）、TC（r=0.42，P=0.00）、LDL（r=0.03，P=0.01）、Cr（r =0.64，P=0.00）、UA（r=0.54，P=0.00）呈正相关关系，与e GFR（r=－0.84，P=0.00）呈负相关关系。通过ROC曲线得出，RI=0.70为判定DN患者肾功能轻度受损（GFR<90(ml·min-1(1.73 m2)-1)）的截断参考值，其敏感性为84.1%，特异性为92.9%，在此参考值上A-IMT明显增厚，具有显著差异(P<0.05)。A-IMT及e GFR是肾动脉RI值的独立影响因素(P均<0.05)。结论：应用彩色超声多普勒技术可无创地获得DN患者肾内动脉RI值和腹主动脉内-中膜厚度，能够客观、便捷地评价DN患者微血管和大血管的受损情况，具有重要的临床意义。 |
| 英文摘要: |
| Objective: To evaluate the correlation between intra-renal arterial resistance index (RI) and aortic intima-media thickness (A-IMT) in .the patients of type 2 diabetic nephropathy by color Doppler ultrasonography. Methods: Ninety-three patients with type 2 diabetic nephropathy were enrolled and divided into three groups according to the level of glomerular filtration rate (GFR):GFR≥90 ml·min-1·(1.73 m2)-1 as group B (33 cases), 60 ml·min-1·(1.73 m2)-1≤GFR＜90 ml·min-1·(1.73 m2)-1as group C (31 cases), and GFR＜60 ml·min-1·(1.73 m2)-1 as group D (29 cases). 35 healthy volunteers were enrolled as the control group (group A). The intra-renal arterial RI and aortic intima-media thickness were obtained by color Doppler Ultrasonography.. Results: The values of RI and A-IMT of group B, C, D were significantly larger than those of group A (all P＜0.05). Values of RI and A-IMT of the group C, D were significantly larger than those of group B (all P＜0.05). Values of RI and A-IMT of group D were significantly larger than those of group C (all P＜0.05). RI was positively correlative with A-IMT（r =0.90，P=0.00）、HbA1C（r =0.58，P=0.00）、Glu（r =0.67，P=0.00）、TC（r =0.42，P=0.00）、LDL（r =0.03，P=0.01）、Cr（r =0.64，P=0.00）、UA（r =0.54，P=0.00） and negatively correlative with e GFR（r =－0.84，P=0.00）respectively. RI=0.70 was selected to be the cut-off point as an indicator of mild renal damage in the DN patients. The patients with RI above 0.70 had higher A-IMT than those with lower value (P＜0.05). A-IMT and e GFR were independent predictors of RI. Conclusion: The intra-renal arterial RI and A-IMT in the patients of type 2 diabetic nephropathy can be obtained by color Doppler ultrasonography noninvasively. The microvascular and macrovascular injuries of the patients with type 2 diabetic nephropathy can be evaluated objectively and conveniently with important clinical significance. |
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