| 夏亭亭,尤晓婷,梁嘉敏,郑吴熙,邓恩昕,李靖煦,刘远明,关玉宝.定量CT对比观察轻-中度慢性阻塞性肺疾病及哮喘[J].中国医学影像技术,2020,36(3): |
| 定量CT对比观察轻-中度慢性阻塞性肺疾病及哮喘 |
| Comparision of mild-to-moderate chronic obstructive pulmonary disease and asthma with quantitative CT |
| 投稿时间：2019-06-29 修订日期：2020-02-16 |
| DOI： |
| 中文关键词: 肺疾病，慢性阻塞性 哮喘 气道重塑 体层摄影术，X线计算机 |
| 英文关键词:pulmonary disease,chronic obstructive Asthma Airway remodeling tomography,X-ray computed |
| 基金项目:广东省科技计划项目；深圳市海外高层次人才创新创业专项资金 |
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| 中文摘要: |
| 目的 观察稳定期轻-中度慢性阻塞性肺疾病(COPD)与哮喘患者近端气道结构及CT肺功能的差异。方法 30例轻-中度COPD患者（mtmCOPD组）、30例轻-中度哮喘患者(mtmAs组)及30名健康对照者（健康对照组）行低剂量呼吸双相CT扫描及定量分析，比较其近端气道参数、肺气肿及空气潴留指数的差异。结果 mtmCOPD及mtmAs组近端气道平均管腔面积（LA）/体表面积(BSA)分别为（(10.93±2.58)mm2/m2 和(10.81±3.20)mm2/m2），均小于健康对照组的(12.56±2.98)mm2/m2），mtmAs组与健康对照组差异有统计学意义（P =0.04）；mtmCOPD组和mtmAs组平均管壁面积百分比（WA%）分别为(63.02±2.34)% 和 (63.85±2.48)%），均大于健康对照组的(61.55±3.54)%，mtmAs组与健康对照组差异有统计学意义（P ＜0.01）。mtmCOPD组呼吸双相VI-910(%)及VI-950(%)均大于健康对照组（P 均＜0.01），呼气相平均肺密度（MLD）绝对值、呼气相VI-856(%)及MLD E/I均大于健康对照组（P 均＜0.05）。mtmCOPD组与mtmAs组气道结构参数、肺气肿及空气潴留指数差异均无统计学意义（P 均＞0.05）。结论 轻-中度COPD及哮喘近端支气管的管腔面积较健康对照者均有缩小，近端气道管壁面积百分比较健康对照者均有增大，且轻-中度哮喘患者更加明显。轻-中度COPD患者存在明显的肺气肿及空气潴留。 |
| 英文摘要: |
| Objective To investigate the differences of proximal airway structure and CT pulmonary function between steady mild-to-moderate COPD and asthma patients. Methods Thirty patients with mild-to-moderate COPD(mtmCOPD group), 30 patients with mild-to-moderate asthma(mtmAs group) and 30 healthy controls(normal control group) underwent low-dose paired inspiratory and expiratory CT scans and quantitative analysis. The differences of airway parameters, emphysema index and air trapping index were analysed among 3 groups. Results The mean lumen area (LA)/body surface area(BSA) of the proximal airway of both mtmCOPD goup and mtmAs group ([10.93±2.58]mm2/m2 , [10.81±3.20] mm2 / m2 ) were lower than that of normal control group ([12.56±2.98] mm2/m2), and statistically significant difference was found between the mtmAs group and normal control group( P = 0.04). The mean WA% of both mtmCOPD group and mtmAs group ([63.02±2.34)] ,[63.85±2.48]% ) were higher than that of normal control group ([61.55 ±3.54]%), while statistically significant difference was observed between the mtmAs group and normal control group (P < 0.01). The paired inspiratory and expiratory VI-910 (%) and VI-950 (%) of mild-to-moderate COPD were higher than those of healthy controls (all P < 0.01). The expiratory absolute value of mean lung density (MLD), expiratory VI-856 (%) and MLD E/I of mtmCOPD were also higher than those of normal control group( all P < 0.05). There was no significant difference in airway structural parameters, emphysema nor air trapping index between mtmCOPD and mtmAs. Conc. Meanwhile, the percentage of proximal airway wall area were both larger than that of healthy controls, which were more obviously in patients with mild-to-moderate asthma. There were obvious emphysema and air trapping in mild-to-moderate COPD than in healthy controls. |
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