| 曹宪宪,高小燕,于楠,师美娟,魏霞,金晨望,郭佑民.呼气相CT定量分析肺血管在COPD中的应用[J].中国医学影像技术,2020,36(3): |
| 呼气相CT定量分析肺血管在COPD中的应用 |
| Application of expiratory CT in quantitative analysis of pulmonary vessels in COPD |
| 投稿时间：2019-06-27 修订日期：2020-02-16 |
| DOI： |
| 中文关键词: 肺疾病，慢性阻塞性 肺血管 体层摄影术，X线计算机 |
| 英文关键词:Pulmonary disease, chronic obstructive pulmonary vessel Tomography X-ray computed |
| 基金项目:国家卫生和计划生育委员会公益性行业科研专项基金（201402013） |
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| 中文摘要: |
| 目的 基于计算机辅助测量慢性阻塞性肺疾病（Chronic obstructive lung disease , COPD）患者呼、吸双相CT肺内血管体积（Intrapulmonary vascular volume , IPVV），探讨呼气相CT定量肺血管在COPD中的应用价值。 方法 回顾性收集COPD患者89例，均行吸气相、呼气相CT扫描及肺功能检查（PFT），基于“数字肺”数据分析平台定量测量呼、吸双相CT扫描下IPVV。应用Pearson或Spearman相关系数分别评估吸、呼气相下IPVV与PFT参数的相关性。结果 吸气相下各肺叶IPVV与PFT参数呈负相关（r=-0.215～-0.358,P<0.01）；呼气相下各肺叶IPVV与PFT参数呈负相关（r=-0.238～0.387,P<0.01）；呼气相IPVV与PFT的相关性大于吸气相。呼吸状态下IPVV变化量与PFT呈正相关（r=0.211～0.463,P<0.01）。结论 双气相CT可定量评估COPD肺血管体积及呼吸状态下肺血管变化量，呼气相CT定量分析肺血管为评估COPD患者呼气气流阻塞程度提供更多有效信息，为进一步研究COPD相关肺动脉高压提供新的途径。 |
| 英文摘要: |
| Objective To evaluate intrapulmonary vascular volume on paired inspiratory and expiratory CT in patients with chronic obstructive pulmonary disease (COPD), and explore the value of expiratory CT quantitative pulmonary vascular in COPD. Methods Eighty-nine COPD patients were collected retrospectively from the “Digital Lung” database. All subjects underwent both inspiratory and expiratory CT scans and the intrapulmonary vascular volume (IPVV) of the whole lung and individual lobes were quantitatively analyzed. The correlations between IPVV and PFT parameters were analyzed using Pearson or Spearman’s rank correlation coefficients. Results In inspiratory scan, IPVV was negatively correlated with PFT parameters（r=-0.215～-0.358,P<0.01）; In expiratory scan, IPVV was negatively correlated with PFT parameters（r=-0.238～0.387,P<0.01）; The correlation coefficients in expiratory CT were greater than that in inspiratory. The change of IPVV in respiratory state was positively correlated with PFT parameters（r=0.211～0.463,P<0.01）. Conclusion Paired inspiratory and expiratory CT can quantitatively evaluate IPVV and pulmonary vascular changes in respiratory state of COPD. The expiratory CT can provide more effective information for assessing the degree of expiratory airflow obstruction in COPD patients, and provide a new approach for studying pulmonary hypertension in COPD. |
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