| 李培杰,张永高,高剑波,赵清霞.基于冠脉CTA对HIV感染者冠状动脉易损斑块的研究[J].中国医学影像技术,2020,36(3): |
| 基于冠脉CTA对HIV感染者冠状动脉易损斑块的研究 |
| Study on vulnerable coronary plaques in HIV-infected patients based on coronary computed tomography angiography |
| 投稿时间：2019-06-10 修订日期：2020-03-19 |
| DOI： |
| 中文关键词: 冠状动脉 易损斑块 人类免疫缺陷病毒 体层摄影术 X线计算机 |
| 英文关键词:coronary artery vulnerable plaque human immunodeficiency virus tomography X-ray computer |
| 基金项目:非基金项目 |
|
| 摘要点击次数: 2473 |
| 全文下载次数: 514 |
| 中文摘要: |
| 目的 探索HIV感染者冠脉易损斑块是否与非HIV感染者存在差异，并进一步分析HIV感染者冠脉易损斑块的相关危险因素。方法 收集行CCTA检查的HIV感染者167例及非感染者185例，将存在两种或两种以上高危形态学特征的斑块定义为易损斑块，对比分析两组患者冠脉易损斑块的类型、位置及发生率，并分析HIV感染者冠脉易损斑块的相关危险因素。结果 两组患者基线临床资料无明显差异。两组患者最常见的易损斑块类型均为低衰减斑块+正性重构，多位于前降支近段（S6）；HIV感染者≥1个冠脉节段出现易损斑块的发生率较非感染组增加（34.73% VS 24.32%，P<0.05）。HIV感染者冠脉易损斑块与ART药物治疗时间独立相关[OR 1.29，95%CI(1.04，1.59)]，P=0.02。结论 HIV感染者冠脉易损斑块的发生率较非感染者增加，ART药物治疗可能是HIV感染者出现冠脉易损斑块的独立危险因素。 |
| 英文摘要: |
| Objective To explore whether the vulnerable coronary plaques of HIV-infected patients are different from the non-infected patients and further to analyze the risk factors associated with vulnerable coronary plaques in HIV-infected patients. Methods 167 HIV-infected patients and 185 non-infected patients who underwent CCTA were collected. Vulnerable plaques were defined as those with two or more high-risk morphological features. The types, locations and incidences of vulnerable coronary plaques in the two groups were compared and analyzed, and the risk factors associated with vulnerable coronary plaques in HIV-infected patients were analyzed. Results There was no significant difference in baseline clinical data between the two groups. The most common type of vulnerable coronary plaques in the two groups were low attenuation plaques+positive remodeling, and which were mostly located in the proximal segment of left anterior descending artery(segment6). The incidence of vulnerable coronary plaques ≥1 coronary segments in HIV-infected patients was higher than that in non-infected patients(34.73% VS 24.32%，P<0.05). Vulnerable coronary plaques in the HIV-infected patients were independently correlated with the duration of ART drug use[OR 1.29,95%CI(1.04,1.59)],P=0.02. Conclusion The incidence of vulnerable coronary plaques in HIV-infected patients was higher than that in non-infected patients. ART drug use may be an independent risk factor for coronary plaque vulnerability in HIV-infected patients. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
