| 林澜,吕晋浩,张荣举,罗春材,马笑笑,韩东山,田成林,王君,马林,娄昕.全脑CT灌注成像定量分析颅内动脉粥样硬化性狭窄患者血管表面渗透性[J].中国医学影像技术,2020,36(5): |
| 全脑CT灌注成像定量分析颅内动脉粥样硬化性狭窄患者血管表面渗透性 |
| Quantitative Analysis of Vascular Surface Permeability in Patients with Intracranial Atherosclerotic Stenosis by Whole Brain CT Perfusion Imaging |
| 投稿时间：2019-06-02 修订日期：2020-05-18 |
| DOI： |
| 中文关键词: 颅内动脉粥样硬化性狭窄 全脑CT灌注成像 血管表面渗透性 |
| 英文关键词:Intracranial atherosclerotic stenosis Computed tomography perfusion Permeability |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 目的 采用全脑CT灌注成像研究颅内动脉粥样硬化性狭窄（ICAS）患者血管表面渗透性(PS)变化及治疗后改变，分析其与临床资料相关性。方法 纳入ICAS患者59例及16例对照者,根据责任动脉供血区,勾画感兴趣区测量PS、脑血流量(CBF)、血容量(CBV)及平均通过时间(MTT)，并获得对侧镜像值,比较ICAS组与对照组PS及灌注参数差异，并分析17例ICAS患者支架置入前、后PS及灌注参数改变，及PS与临床资料相关性。结果 ICAS组与对照组比较，患侧PS值增高，CBF减低、MTT延长，差异均有统计学意义（P＜0.05），CBV减低不具有统计学差异（P＞0.05）。ICAS组狭窄侧与对侧相比，PS值增高、CBF减低、CBV增加、MTT延长，支架置入术后患侧PS值降低，CBF、MTT改变，差异均具有统计学意义（P＜0.05）；PS值与房颤呈轻度负相关(P＜0.05)。结论 全脑灌注CT成像可定量评价ICAS患者微循环灌注及血管表面渗透性状态，对治疗决策起指导作用，血管表面渗透性可以做为定量评价治疗有效性的标志物。 |
| 英文摘要: |
| Objective Whole brain CT perfusion imaging was used to study the changes of permeability surface area-product (PS) and post-treatment changes in patients with intracranial atherosclerotic stenosis (ICAS), and to analyze their correlation with clinical data. Methods 59 patients with ICAS and 16 controls were included. Draw ROI to measure PS, CBF, CBVand MTT based on the responsible artery blood supply area，and the contralateral mirror value was obtained. The differences in PS and perfusion parameters between the ICAS group and the control group were compared, and the changes of PS and perfusion parameters before and after stent implantation in 17 ICAS patients were analyzed, and the correlation between PS and clinical data. Results Compared with the control group, the ICAS group had higher PS value, lower CBF, and longer MTT，the differences were statistically significant (P <0.05), and the CBV reduction was not statistically significant (P> 0.05). Compared with the contralateral side in the ICAS group, the PS value increased, the CBF decreased, the CBV and MTT increased, after the stent placement, the PS value of the affected side was significantly reduced, and the CBF and MTT changes were statistically significant (P <0.05); There was a slight negative correlation between PS value and atrial fibrillation (P <0.05). Conclusion Whole brain perfusion CT imaging can quantitatively evaluate the microcirculation perfusion and vascular surface permeability of patients with ICAS, which can guide the treatment decision. PS can be used as a marker to quantitatively evaluate the effectiveness of treatment. |
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