| 马巧稚.3D-T1-VIBE 序列在膝关节G-ACI术后软骨修复评价中的应用价值[J].中国医学影像技术,2020,36(2): |
| 3D-T1-VIBE 序列在膝关节G-ACI术后软骨修复评价中的应用价值 |
| Application of 3D-T1-VIBE sequence in short term following up for fibrin matrix-mixed gel-type autologous chondrocyte implantation (G-ACI) of the knee |
| 投稿时间：2019-05-30 修订日期：2020-02-21 |
| DOI： |
| 中文关键词: 磁共振成像 软骨 纤维蛋白凝胶型自体软骨细胞移植 |
| 英文关键词:Magnetic resonance imaging Cartilage Fibrin matrix-mixed gel-type autologous chondrocyte implantation |
| 基金项目:解放军总医院第三医学中心院内科研基金 |
|
| 摘要点击次数: 2037 |
| 全文下载次数: 406 |
| 中文摘要: |
| 目的 探讨三维容积内插屏气扫描（3D-T1-VIBE）序列在纤维蛋白凝胶型自体软骨细胞移植（G-ACI）术后修复软骨评估中的应用价值。方法 10例单侧膝关节软骨运动损伤男性部队官兵接受G-ACI手术，术后1、3、6个月分别行磁共振成像（MRI）检查，扫描序列包括常规序列及3D-T1-VIBE序列，影像表现采用MOCART评分系统，采用单因素方差分析比较术后不同时期MOCART评分系统中“软骨缺损修复填充程度”等9项观察指标；临床采用膝关节损伤和骨关节炎评分（KOOS），包括疼痛等5个子项，并与MOCART整体评分做Spearman相关性分析。结果 1、MOCART评分结果显示，“软骨缺损修复填充程度”较整体评分更早反映出评分差异；术后6个月，“修复组织与相邻正常软骨的融合”、“修复组织表面结构”、“软骨信号强度”、“粘连”情况较前好转，差异有统计学意义（P＜0.05），而“修复组织内部结构”差异无统计学意义（P=0.17＞0.05）；2、MOCART评分与临床KOOS评分5个子项的相关性分析结果：“修复组织表面结构” 及“软骨缺损修复填充程度”与KOOS评分具有较好的相关性。术后3、6个月，“修复组织表面结构”与“疼痛”相关系数分别为：0.72、0.81；术后6个月，“修复组织表面结构”与“疼痛”、“日常活动”相关系数分别为：0.81、0.88；“软骨缺损修复填充程度”与“症状”、“运动与娱乐”相关系数分别为：0.70、0.82，P值均小于0.05，均呈正相关；余观察指标与KOOS评分均未见明显相关性。结论3D-T1-VIBE序列结合磁共振常规扫描序列能较准确的评估G-ACI术后软骨修复情况，且与“疼痛”等临床症状有一定的相关性。 |
| 英文摘要: |
| Objective To evaluate the application value of 3D-T1-VIBE sequence for fibrin matrix-mixed gel-type autologous chondrocyte implantation (G-ACI) on patients with cartilage injury in knee. Methods MRI was performed at 1, 3, and 6 months postoperation in 10 patients with knee cartilage injury. The sequences include conventional sequences and 3D T1-weighted gradient-echo sequence. One-way analysis of variance was used to compare 9 observation indicators of MOCART overall scoring system in different periods after operation. Clinical use of knee injury and osteoarthritis score (KOOS), Includes 5 sub-items. And the overall score of MOCART was used for Spearman correlation analysis. Results 1. MOCART scores show that 1, 3, and 6 months after surgery, "Cartilage defect repair filling degree" and MOCART total grouping differences were statistically significant（P＜0.01). There was a statistically significant difference between "reconstruction of tissue and adjacent normal cartilage", "repair of tissue surface structure" and "chondral signal intensity" at 1 and 6 months after operation（P＜0.05）. The difference of "with or without adhesion" was statistically significant at 3 and 6 months after surgery（P＜0.05）. 2. Correlation analysis results of MOCART score and clinical KOOS score 5 sub-items: At 3 and 6 months after surgery, “repaired tissue surface structure” and “cartilage defect repair filling degree” were positively correlated with KOOS score，P＜0.05. Conclusion 3D-T1-VIBE sequence combinedconventional magnetic resonance scanning sequences can accurately evaluate the cartilage repair after G-ACI, and it has a certain correlation with clinical symptoms. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
