| 程仲元,冯友珍,胡俊娇,林绮婷,蔡香然.磁共振扩散张量成像评估高尿酸血症患者肾损伤的初步研究[J].中国医学影像技术,2020,36(4): |
| 磁共振扩散张量成像评估高尿酸血症患者肾损伤的初步研究 |
| The preliminary study of diffusion tensor imaging for assessing kidney injury in patients with hyperuricemia |
| 投稿时间：2019-04-29 修订日期：2020-04-13 |
| DOI： |
| 中文关键词: 肾脏 高尿酸血症 扩散张量成像 血清尿酸 eGFR |
| 英文关键词:kidney hyperuricemia diffusion tensor imaging SUA, eGFR |
| 基金项目:广东省自然科学基金项目（2017A030313901），广州市科技计划项目（201804010239） |
|
| 摘要点击次数: 1739 |
| 全文下载次数: 459 |
| 中文摘要: |
| 目的：探讨磁共振扩散张量成像在高尿酸血症患者肾功能评价中的应用价值。
材料与方法：收集2016年2月至2017年2月我院临床确诊的男性无症状高尿酸血症患者（AH）23例、痛风患者（GA）30例及年龄和性别匹配的健康志愿者（HC）23例。采用 GE HD 3.0T Discovery MR750 超导型扫描仪，双肾冠状位DTI成像，b值为0和800s/mm2，16个扩散敏感梯度方向，在后处理工作站测量肾皮质和髓质ADC值和FA值。采用单因素方差分析（Bonferroni检验/Tamhane’s T2法）比较各组间肾皮质、髓质的DTI各参数值，并与SUA和eGFR行Pearson相关性分析。此外，也计算SUA与eGFR之间的相关性。
结果：AH组与GA组肾皮质和髓质的FA值均明显低于对照组（p＜0.05）；AH组、GA组肾皮质的ADC值和GA组肾髓质的ADC值均明显低于对照组（p＜0.05）。DTI参数与SUA均呈明显负相关关系（p＜0.05），而与eGFR值间均无明显相关性（p＞0.05）。此外，eGFR与SUA呈明显负相关关系（r=-0.428，p=0.000）。
结论：DTI能够用于高尿酸血症患者早期肾功能改变的评估。 |
| 英文摘要: |
| Diffusion tensor imaging (DTI) of the kidneys in patients with hyperuricemia
ABSTRACT
CHENG zhong-yuan，FENG you-zhen，HU jun-jiao，LIN qi-ting, CAI xiang-ran*
（Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China）
Objective: The objective of this study was to evaluate the utility of DTI parameters to identify the early changes of the kidneys in patients with hyperuricemia.
Materials and methods: A total of 76 male participants, including asymptomatic hyperuricemia (AH, 23 cases), gouty arthritis (GA, 30 cases) and 23 age- and sex-matched healthy controls (HC), were enrolled in this study. All subjects underwent DTI sequence with the b-values of 0 and 800s/mm2 on a 3.0T MRI scanner. Mean cortical and medullary DTI parameters (ADC and FA values) were calculated by setting multiple regions of interest. Differences in the DTI parameters among the three groups were assessed. In addition, DTI parameters were correlated with serum uric acid (SUA) and estimated glomerular filtration rate (eGFR). Also, the correlation between the SUA and eGFR was calculated.
Results: The FA values of renal cortex and medulla significantly decreased in the AH and GA groups compared to the control group (p<0.05). The cortical ADC values in the AH and GA groups and medullary ADC value in the GA group were significantly lower than that of control group (p<0.05). The ADC and FA values of renal cortex or medulla were negatively correlated with SUA (p<0.05), while no significant correlation was found between these values and eGFR (p>0.05). Also, there was a significantly negative correlation between the eGFR and SUA (r=-0.428, p=0.000).
Conclusion: DTI can detect the early changes of renal function in patients with hyperuricemia. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
