| 侯孟岩,孟楠,张梦,刘文玲,韩东明,任继鹏.氨基质子转移成像及扩散峰度成像诊断宫颈鳞癌分级的价值[J].中国医学影像技术,2020,36(4): |
| 氨基质子转移成像及扩散峰度成像诊断宫颈鳞癌分级的价值 |
| The value of amide proton transfer imaging and diffusion kurtosis imaging in diagnosing cervical squamous cell carcinoma |
| 投稿时间：2019-04-24 修订日期：2020-04-13 |
| DOI： |
| 中文关键词: 宫颈鳞癌 磁共振成像 氨基质子转移成像 扩散峰度成像 |
| 英文关键词:Cervical squamous cell carcinoma magnetic resonance imaging amide proton transfer imaging diffusion kurtosis imaging |
| 基金项目:河南省医学科技攻关计划项目 |
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| 中文摘要: |
| [摘 要] 目的 评价氨基质子转移成像（APT）及扩散峰度成像（DKI）在诊断宫颈鳞癌分级中的价值。方法 回顾性分析36例宫颈癌鳞癌[高分化组（11例）、中分化组（16例）、低分化组（9例）]患者的APT、DKI影像资料，测量宫颈鳞癌组织的不对称性磁化转移率（MTRasym）、平均扩散峰度（MK）、平均扩散系数（MD）值。比较各组宫颈鳞癌MTRasym、MK、MD值的差异；采用ROC曲线评价各参数的诊断效能，采用Spearman相关分析检验各参数与组织学分级之间的相关性。结果 2位观察者测得各参数值的一致性高（均ICC＞0.75，均P＜0.01）。MTRasym、MK、MD值在高、中、低分化组间差异均具有统计学意义（P<0.01）；两两组间比较，各参数值差异均具有统计学意义（P<0.01）；在鉴别高、中分化宫颈鳞癌中，MTRasym、MK及MD值的诊断阈值分别为2.97、 0.86和1.03×10-3mm2/s，ROC曲线下面积分别为0.85、0.82、0.83；在鉴别中、低分化宫颈鳞癌中，MTRasym、MK及MD值的诊断阈值分别为3.05、 0.90和0.96×10-3mm2/s，ROC曲线下面积分别为0.90、0.82、0.78；MK值、MTRasym值与病理分级呈正相关（r=0.78,0.69，P<0.01），MD值与病理分级呈负相关（r=-0.68，P<0.01）。 结论 APT和DKI参数中的MTRasym、MK、MD值均有助于诊断宫颈鳞癌分级。 |
| 英文摘要: |
| [Abstract] Objective To explore the value of amide proton transfer imaging (APT) and diffusion kurtosis imaging (DKI) in diagnosing cervical squamous cell carcinoma. Methods The APT and DKI images of 36 patients with cervical squamous cell carcinoma were retrospectively analyzed. The MTRasym , MK and MD values of cervical squamous cell carcinoma were measured. The differences of the parameters between the highly differentiated group (n = 11), the moderately differentiated group (n = 16), and the poorly differentiated group (n = 9) was compared. The ROC curve was used to evaluate the diagnostic efficiency of each parameter, and the correlation between each parameter and histological grade was analyzed by Spearman rank correlation. Results The parameters measured by 2 radiologists exhibited excellent interobserver agreement（all ICC＞0.75，P<0.01）. The differences of MTRasym , MK and MD values were statistically significant among the highly, moderately and poorly differentiation groups (P<0.01). The parameters between any differentiated degree differentiation cervical squamous cell carcinoma has significant difference(P<0.01). When differentiating the highly from the moderately cervical squamous cell carcinoma, the diagnostic thresholds of MTRasym, MK, and MD values were 2.97, 0.86, and 1.03×10-3 mm2/s, respectively, the areas under the curve were 0.85, 0.82 and 0.83 respectively. When differentiating the moderately from the poorly cervical squamous cell carcinoma, the diagnostic thresholds of MTRasym, MK, and MD values were 3.05，0.90and 0.96×10-3mm2/s, respectively, the areas under the curve were 0.90,0.82 and 0.78, respectively. And MK and MTRasym value were positively correlated with pathological grade (r=0.78, 0.69, P<0.01), the MD value was negatively correlated with pathological grade (r=-0.68, P<0.01). Conclusion The MTRasym, MK, and MD values from APT and DKI parameters are helpful to diagnosis the grades of cervical squamous cell carcinoma. |
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