| 杨蔚.MR功能成像联合临床预后因素预测宫颈鳞癌同步放化疗疗效[J].中国医学影像技术,2020,36(3): |
| MR功能成像联合临床预后因素预测宫颈鳞癌同步放化疗疗效 |
| MR functional imaging combined with clinical prognostic factors for predicting response to concurrent chemoradiotherapy in cervical squamous cell cancer |
| 投稿时间：2019-04-15 修订日期：2020-03-16 |
| DOI： |
| 中文关键词: 磁共振成像 动态对比增强磁共振成像 扩散加权成像 宫颈癌 同步放化疗 |
| 英文关键词:Magnetic resonance imaging Dynamic contrast-enhanced MR imaging Diffusion-weighted imaging Cervical cancer Concurrent chemoradiotherapy |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 目的 评估功能MR成像联合临床预后因素（CPF）预测宫颈鳞癌患者同步放化疗（CCRT）的疗效。方法 59例宫颈鳞癌患者CCRT治疗前在3.0T MR上进行常规MRI，DWI和DCE-MRI扫描。根据CCRT治疗后三个月的随访MRI并结合临床检查，将患者分为两组：有肿瘤残余和无肿瘤残余组。比较两组之间的功能MRI参数和CPF（肿块大小，FIGO分期，淋巴结转移）的差异。结果 肿瘤残余组在治疗前肿瘤低强化区域的最大上升斜率（MSIL）和信号强化率（SERL）显著低于无肿瘤残余组，而ADC值和FIGO分期，淋巴结转移高于无肿瘤残余组（P均<0.05）。将MSIL和ADC值结合预测CCRT治疗后肿瘤残余发生的诊断效能高于单个MRI参数；MRI多参数与CPF结合进一步提高了预测效能。结论 治疗前MSIL和ADC值是CCRT治疗后肿瘤残余发生的独立预后因素。MRI多参数与CPF结合预测CCRT疗效的诊断效能最高。 |
| 英文摘要: |
| Objective To predict response to concurrent chemoradiotherapy (CCRT) through a combination of functional MRI with clinical prognostic factors（CPF）in patients with cervical squamous cell carcinoma (SCC). Methods Fifty-nine patients with SCC underwent conventional MRI, DWI and DCE-MRI before CCRT. The patients were divided into non- and residual tumour groups according to post-treatment 3 month MRI combined with clinical examination. Pre-treatment functional MRI parameters and CPF between the two groups were compared. Results There were a significantly lower pre-treatment MSIL and SERL , higher ADC value, FIGO staging and lymph node metastasis in post-treatment residual tumors group than in non-residual tumors group(P all <0.05). A combination of MSIL and ADC with CPF improved a diagnostic performance compared with individual MRI parameter. Conclusions Pre-treatment MSIL and ADC were independent prognostic factors for post-treatment residual tumor. The combination of multi-parametric MRI with CPF exhibited the highest predictive performance. |
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