| 李进叶,李龙,孙立新,赵慧,许挺,田静,胡娜,黄一帆,巩若箴.经鼓室和静脉给药内耳3D-FLAIR在梅尼埃病应用的对比研究[J].中国医学影像技术,2020,36(1): |
| 经鼓室和静脉给药内耳3D-FLAIR在梅尼埃病应用的对比研究 |
| A 3D FLAIR imaging comparison study with intratympanic or intravenous gadolinium injection in Meniere's disease |
| 投稿时间：2019-04-11 修订日期：2020-01-04 |
| DOI： |
| 中文关键词: 3D FLAIR 梅尼埃病 内淋巴积水 |
| 英文关键词:3D FLAIR Meniere's disease Endolymphatic hydrops |
| 基金项目:山东省重点研发计划 |
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| 中文摘要: |
| 目的 利用3D FLAIR MRI比较经鼓室和静脉两种给药方法在梅尼埃病患者的迷路成像中的区别。方法 收集的36例单侧梅尼埃病患者,一组（18人）经双侧鼓膜分别注射等量的８倍稀释的Gd-DTPA，另一组（18人）经肘静脉注射GD-BOPTA（0.4ml/kg），分别在24h和4h后行内耳3D FLAIR MRI扫描。观察迷路显影情况，分别在双侧耳蜗底转增强区域及同层脑干画ROI，并分别计算两组耳蜗底转及同层脑干的信号强度比值（CM比值），并两两比较CM比值。记录两种方法显示耳蜗、前庭内淋巴积水情况。利用配对t检验分析两组CM比值有无差异，利用卡方检验分析两组显示内淋巴积率的差异。结果 经静脉组患耳CM 比值（1.46±0.31）高于正常耳（1.26±0.21,P=0.001）。经鼓室组患耳CM 比值（1.87±0.76,n=18）高于经静脉组CM 比值（1.46±0.31,n=18;P=0.044）。结论 根据病人临床特点、临床需求选择适合的给药方法以观察内耳影像。 |
| 英文摘要: |
| Objective：To determine whether intratympanic (IT) or intravenous (IV) injection of gadolinium is more suitable for labyrinthine lymph imaging of patients with vertigo disease. Methods In total thirty-six patients with unilateral vertigo disease were recruited in this study. Eighteen of them were randomly selected and underwent a bilateral IT method (GD-DTPA was diluted 8-fold and injected 24hrs prior to the MR experiments) .The rest eighteen patients were then injected with GD-BOPTA (0.4mL/kg body weight) using an IV-method 4hrs before the MR experiments. All experiments were performed on a 3T clinical scanner. Regions of interest
of the cochlear perilymph and the medulla oblongata were determined on each image, and the
signal-intensity ratio between the 2 (CM ratio) was subsequently evaluated. In addition, the number of EH in labyrinthine were separately determined for each patient. The differences in the CM ratio between the 2 groups (paired t test) and the EHN ratios between the two methods (chi-squared test) were evaluated. Results For the IV injection group, a significant difference for CM ratios was observed between the affected and unaffected sides of perilymph regions (1.46 ± 0.31 vs 1.26 ± 0.21, P=0.001). Meanwhile, significantly higher values were shown in both the affected (1.86 ± 0.74 vs 1.46 ± 0.31, P=0.044) sides of perilymph for IT group than for IV group. Conclusion The appropriate technique must be chosen with consideration of the clinical characteristics and demand of each patient. |
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