| 刘芮菁,王晓庆,李德毅,朱佳琳,桑睿,魏玺.基于多模态超声表现分析微波消融用于甲状腺良性结节早期效果的影响因素[J].中国医学影像技术,2026,42(6):931~935 |
| 基于多模态超声表现分析微波消融用于甲状腺良性结节早期效果的影响因素 |
| Analysis of impact factors of early effect of microwave ablation for benign thyroid nodules based on multimodal ultrasound manifestations |
| 投稿时间：2025-11-30 修订日期：2026-04-26 |
| DOI：10.13929/j.issn.1003-3289.2026.06.029 |
| 中文关键词: 甲状腺结节 消融技术 超声检查 |
| 英文关键词:thyroid nodule ablation techniques ultrasonography |
| 基金项目:国家自然科学基金(82402274)、天津市医学重点学科建设项目(TJYXZDXK-009A)、国家重点研发计划课题(2024YFA1802702)、国家科技重大专项(2024ZD0525602)、天津市教委科研计划项目(2025ZD002)。 |
| 作者 | 单位 | E-mail | | 刘芮菁 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | | | 王晓庆 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | | | 李德毅 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | | | 朱佳琳 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | | | 桑睿 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | | | 魏玺 | 天津医科大学肿瘤医院超声诊疗科, 国家恶性肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060 | weixi@tjmuch.com |
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| 中文摘要: |
| 目的 基于多模态超声表现分析微波消融(MWA)用于甲状腺良性结节(BTN)早期效果的影响因素。方法 回顾性纳入40例BTN患者,根据MWA后3个月病变体积缩小率(VRR)划分疗效良好组(VRR≥48%,n=22)与疗效不佳组(VRR＜48%,n=18);比较组间治疗前常规超声、CDFI、超声造影(CEUS)、超微血管成像(SMI)及显微超声造影(SR CEUS) 表现;将P＜0.1的变量纳入多因素logistic回归分析,筛选BTN经MWA后早期效果的独立影响因素。结果 组间BTN钙化、与被膜关系、CEUS增强速度及SR CEUS微血流模式差异均有统计学意义(P均＜0.05)。CEUS快增强及均匀增强为BTN经MWA后早期效果的独立危险因素,SR CEUS微血流模式规则为其独立保护因素(P均＜0.05)。结论 CEUS快增强及均匀增强为MWA用于BTN早期效果的独立危险因素,而SR CEUS微血流模式规则为其独立保护因素。 |
| 英文摘要: |
| Objective To explore the impact factors of early effect of microwave ablation (MWA) for benign thyroid nodules (BTN) based on multimodal ultrasound manifestations. Methods Forty patients with BTN were retrospectively enrolled. According to the volume reduction rate (VRR) of BTN 3 months after MWA, the patients were divided into good efficacy group (VRR≥48%, n=22) and poor efficacy group (VRR＜48%, n=18). Pre-treatment multimodal ultrasound manifestations of BTN, including conventional ultrasound, CDFI, contrast-enhanced ultrasound (CEUS), superb microvascular imaging (SMI) and super resolution contrast-enhanced ultrasound (SR CEUS) were compared between groups. Variables with P＜0.1 were included in multivariate logistic regression to identify the independent impact factors of early effect of MWA for BTN. Results Significant differences of nodule calcification, relationship with the thyroid capsule, enhancement speed on CEUS, as well as SR CEUS microvascular pattern were observed between groups (all P＜0.05). Rapid enhancement and homogeneous enhancement on CEUS were both the independent risk factors, while regular microvascular pattern on SR CEUS was the independent protective factor of early effect of MWA for BTN (all P＜0.05). Conclusion Rapid and homogeneous enhancement on CEUS were the independent risk factors, while regular microvascular pattern on SR CEUS was the independent protective factor of early effect of MWA for BTN. |
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