| 沈畅,李雪齐,刘晗,赵天瑜,张显迪,乔晓慧,程广文,刘少军,丁红.显微超声造影(SR CEUS)评估早期慢性肾病[J].中国医学影像技术,2026,42(6):895~898 |
| 显微超声造影(SR CEUS)评估早期慢性肾病 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for evaluating early chronic kidney disease |
| 投稿时间：2025-11-29 修订日期：2026-05-24 |
| DOI：10.13929/j.issn.1003-3289.2026.06.018 |
| 中文关键词: 肾功能不全,慢性 超声检查 显微超声造影 前瞻性研究 |
| 英文关键词:renal insufficiency, chronic ultrasonography super resolution contrast-enhanced ultrasound prospective studies |
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| 中文摘要: |
| 目的 观察显微超声造影(SR CEUS)评估早期慢性肾病(CKD)的价值。方法 前瞻性纳入39例早期CKD[估算肾小球滤过率(eGFR)≥60 ml/(min·1.73 m2)]患者(CKD组)及41名健康成年人(对照组),通过SR CEUS检查获取肾皮质血管密度(VD)、平均速度(MV)和灌注指数(PI)等微循环定量参数,同时记录eGFR及血肌酐水平。绘制受试者工作特征曲线,计算曲线下面积(AUC),评估各参数诊断早期CKD效能;分析SR CEUS参数与间质纤维化和肾小管萎缩(IFTA)评分的相关性。结果 CKD组VD、MV及PI均低于对照组(P均＜0.05)。eGFR、血肌酐、VD、MV及PI诊断早期CKD的AUC分别为0.752、0.701、0.856、0.784及0.802。VD、MV均与IFTA评分呈负相关(rS=－0.612,P＜0.001;rS=－0.441,P＜0.001);PI与IFTA评分无显著秩相关(P=0.161)。结论 SR CEUS可用于无创评价早期CKD微循环改变。 |
| 英文摘要: |
| Objective To observe the value of super resolution contrast-enhanced ultrasound (SR CEUS) for evaluating early chronic kidney disease (CKD). Methods A total of 39 patients with early CKD (estimated glomerular filtration rate [eGFR] ≥60 ml/ [min·1.73 m2]) (CKD group) and 41 healthy subjects (control group) were prospectively enrolled. SR CEUS examination was performed, and quantitative microcirculation parameters, including renal cortical vessel density (VD), mean velocity (MV) and perfusion index (PI) were obtained, as well as eGFR and serum creatinine. Receiver operating characteristic curve was drawn, the area under the curve (AUC) was calculated to evaluate the diagnostic efficiency of each parameter for diagnosing early CKD. The correlations of SR CEUS parameters and interstitial fibrosis and tubular atrophy (IFTA) score were analyzed. Results VD, MV and PI in CKD group were lower than those in control group (all P＜0.05). The AUC of eGFR, serum creatinine, VD, MV and PI for diagnosing early CKD was 0.752, 0.701, 0.856, 0.784 and 0.802, respectively. Both VD and MV negatively correlated with IFTA scores (rS=－0.612, P＜0.001; rS=－0.441, P＜0.001), while no significant rank correlation was found between PI and IFTA score (P=0.161). Conclusion SR CEUS could be used as a noninvasive tool for evaluating microcirculatory changes of early CKD. |
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