| 黄佳,张济,郑赛,张瑶,胡玉刚,张云敬,周青,邓倾.显微超声造影(SR CEUS)早期检测移植肾功能延迟[J].中国医学影像技术,2026,42(6):890~894 |
| 显微超声造影(SR CEUS)早期检测移植肾功能延迟 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for early detection of delayed renal graft function |
| 投稿时间：2025-11-06 修订日期：2026-05-01 |
| DOI：10.13929/j.issn.1003-3289.2026.06.017 |
| 中文关键词: 肾移植 移植物功能延迟恢复 显微超声造影 |
| 英文关键词:kidney transplantation delayed graft function super resolution contrast-enhanced ultrasound |
| 基金项目:国家自然科学基金(82400791)、湖北省重点实验室开放项目-种子基金(2023KFZZ029)。 |
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| 中文摘要: |
| 目的 探讨显微超声造影(SR CEUS)早期检测移植肾功能延迟(DRGF)的价值。方法 前瞻性纳入65例肾移植术后患者,于术后1~3天完成血清学、常规超声、超声造影(CEUS)及SR CEUS检查,并依据术后7天移植肾功能恢复程度划分DRGF组(n=14)和与非DRGF组(n=51)。对比组间SR CEUS参数,评估各参数早期检测DRGF效能并构建联合预测模型。结果 SR CEUS能清晰显示移植肾微血管结构及灌注状态。DRGF组血管密度(VD)、中值速度(Med Vel)及中值直径(Med D)均低于(P均＜0.001),而达峰时间(TTP)则长于非DRGF组(P＜0.001)。多因素logistic回归分析显示,VD、Med Vel和Med D均为DRGF的独立预测因素(P均＜0.001);基于此构建的联合模型预测DRGF的受试者工作特征曲线下面积为0.913,高于各单一参数(P均＜0.05)。结论 SR CEUS可用于早期检测DRGF。 |
| 英文摘要: |
| Objective To explore the value of super resolution contrast-enhanced ultrasound (SR CEUS) for early detection of delayed renal graft function (DRGF). Methods A total of 65 patients with kidney transplant were prospectively enrolled. Serological testing, as well as conventional ultrasound, contrast-enhanced ultrasound (CEUS) and SR CEUS were performed within 1—3 days after transplantation. Then the patients were divided into DRGF group (n=14) and non DRGF group (n=51) based on the recovery of transplanted kidney function 7 days later. SR CEUS parameters were comparatively analyzed between groups, their efficiency for early detection of DRGF were evaluated, and a combined prediction model was established. Results SR CEUS clearly displayed microvascular structures and perfusion status of transplanted kidneys. Vascular density (VD), median velocity (Med Vel), and median diameter (Med D) were all lower (all P＜0.001), while time to peak (TTP) in DRGF group was longer than in non DRGF group (P＜0.001). Multivariate logistic regression analysis showed that VD, Med Vel and Med D were all independent predictors of DRGF (all P＜0.001). The area under the receiver operating characteristic curve of the combined model constructed based on the above parameters for predicting DRGF was 0.913, higher than each parameter alone (all P＜0.05). Conclusion SR CEUS could be used to early detect DRGF. |
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