| 戚敏,沈会明,李婵,高瑞晨,史进军.显微超声造影(SR CEUS)诊断富于细胞型子宫肌瘤[J].中国医学影像技术,2026,42(6):886~889 |
| 显微超声造影(SR CEUS)诊断富于细胞型子宫肌瘤 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for diagnosing cellular uterine fibroid |
| 投稿时间：2025-11-20 修订日期：2026-05-03 |
| DOI：10.13929/j.issn.1003-3289.2026.06.016 |
| 中文关键词: 子宫肿瘤 肌瘤 显微超声造影 |
| 英文关键词:uterine neoplasms myoma super resolution contrast-enhanced ultrasound |
| 基金项目:东南大学附属中大医院横向科研项目(2025010250)。 |
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| 中文摘要: |
| 目的 观察显微超声造影(SR CEUS)诊断富于细胞型子宫肌瘤的价值。方法 回顾性纳入61例单发子宫肌瘤患者,根据手术病理分为富于细胞型组(n=20)与非富于细胞型组(n=41);比较组间超声造影(CEUS)时间-强度曲线(TIC)参数及SR CEUS定量参数,基于多因素logistic回归构建CEUS模型及SR CEUS模型,对比评估其诊断效能。结果 富于细胞型组TIC时间平均值(mTIC)、峰值强度(PKI)、曲线下面积(AUC)及廓清曲线下面积(WoAUC)均高于非富于细胞型组(P均＜0.05);组间其余CEUS TIC参数差异均无统计学意义(P均＞0.05)。富于细胞型组最大速度(Max Vel)、分形维数(FD)、血流容积(FWVD)及灌注指数(PI)均高于,方向方差(Dir Var)低于非富于细胞型组(P均＜0.05),而组间速度方差(Vel Var)差异无统计学意义(P＞0.05)。基于FD、FWVD及Dir Var构建的SR CEUS模型诊断富于细胞型子宫肌瘤的受试者工作特征曲线下面积(ROC-AUC)高于基于mTIC、PKI及AUC构建的CEUS模型(0.904 vs. 0.884,P＜0.05)。结论 SR CEUS诊断富于细胞型子宫肌瘤效能良好。 |
| 英文摘要: |
| Objective To observe the value of super resolution contrast-enhanced ultrasound (SR CEUS) for diagnosing cellular uterine fibroid. Methods A total of 61 patients with single uterine fibroid were retrospectively enrolled and divided into cellular uterine fibroids group (n=20) and non-cellular uterine fibroids group (n=41) according to surgical pathology. The parameters of time-intensity curve (TIC) of contrast-enhanced ultrasound (CEUS), as well as quantitative parameters of SR CEUS were compared between groups. Based on multivariate logistic regression, CEUS model and SR CEUS model were constructed, respectively, and the diagnostic efficacies were evaluated and compared. Results The mean TIC time (mTIC), peak intensity (PKI), the area under the curve (AUC) and wash-out AUC (WoAUC) in cellular uterine fibroids group were all higher than those in non-cellular uterine fibroids group (all P＜0.05), while no significant difference of the remaining CEUS TIC parameters was found between groups (all P＞0.05). The maximum velocity (Max Vel), fractal dimension (FD), flow-weighted density of vessel (FWVD) and perfusion index (PI) in cellular uterine fibroids group were all higher, while the directional variance (Dir Var) was lower than those in non-cellular uterine fibroids group (all P＜0.05). No significant difference of velocity variance (Vel Var) was found between groups (P＞0.05). The area under the receiver operating characteristic curve (ROC-AUC) of SR CEUS model constructed based on FD, FWVD and Dir Var for diagnosing cellular uterine fibroid was higher than that of the CEUS model constructed based on mTIC, PKI and AUC (0.904 vs. 0.884, P＜0.05). Conclusion SR CEUS had high value for diagnosing cellular uterine fibroid. |
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