| 邱晨,梁增辉,韩天,赵亚楠,钱洁琪,黄品同.显微超声造影(SR CEUS)用于无创诊断肝硬化合并临床显著性门静脉高压[J].中国医学影像技术,2026,42(6):877~880 |
| 显微超声造影(SR CEUS)用于无创诊断肝硬化合并临床显著性门静脉高压 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for non-invasive diagnosis of liver cirrhosis complicated with clinically significant portal hypertension |
| 投稿时间：2025-11-30 修订日期：2026-01-20 |
| DOI：10.13929/j.issn.1003-3289.2026.06.014 |
| 中文关键词: 肝硬化 高血压,门静脉 显微超声造影 |
| 英文关键词:liver cirrhosis hypertension, portal super resolution contrast-enhanced ultrasound |
| 基金项目:浙江省自然科学基金(LTGY24H180002)、国家自然科学基金(82302194)。 |
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| 中文摘要: |
| 目的 观察显微超声造影(SR CEUS)用于无创诊断肝硬化合并临床显著性门静脉高压(CSPH)的价值。方法 前瞻性对33例肝硬化患者行肝脏常规超声及SR CEUS。根据胃镜、实验室检查及超声结果划分CSPH组与非CSPH组,对比组间SR CEUS定性及定量分析结果;针对组间差异有统计学意义的SR CEUS定量参数绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估其诊断肝硬化合并CSPH的效能。结果 33例中,CSPH组23例、非CSPH组10例。SR CEUS显示非CSPH组肝脏微血管充盈较好,呈尚连续的树枝状均匀分布,微血流信号较丰富;而CSPH组微血管密度明显降低,血管走行扭曲、僵硬,呈枯树枝状或斑片状改变,血流信号较非CSPH组减弱。相比非CSPH组,CSPH组血管面积(VA)较小、血管总长度(TVL)较短(P均=0.027)。以VA及TVL诊断肝硬化合并CSPH的AUC分别为0.717及0.743。结论 SR CEUS有助于无创诊断肝硬化合并CSPH。 |
| 英文摘要: |
| Objective To investigate the value of super resolution contrast-enhanced ultrasound (SR CEUS) for non-invasive diagnosis of liver cirrhosis complicated with clinically significant portal hypertension (CSPH). Methods Thirty-three patients with liver cirrhosis were prospectively enrolled, and liver routine ultrasound and SR CEUS were performed. Based on the results of gastroscopy, laboratory tests and ultrasound, the patients were divided into CSPH group and non-CSPH group. Then qualitative and quantitative analysis results of SR CEUS were compared between groups. Receiver operating characteristic (ROC) curves of SR CEUS quantitative parameters being significant different between groups were drawn, the area under the curve (AUC) was calculated to assess their corresponding diagnostic efficacy for diagnosing liver cirrhosis with CSPH. Results Among 33 cases, 23 cases were taken in CSPH group and 10 cases were in non-CSPH group. SR CEUS showed that liver microvessels in non-CSPH group were relatively well-filled and evenly distributed in a nearly continuous tree-like pattern, with abundant microvascular blood flow signals, whereas in CSPH group, liver microvascular density was significantly reduced, the vessel trajectories were distorted and stiff, presented as withered tree-like or patchy changes, and blood flow signals were weaker than those in non-CSPH group. Compared with those in non-CSPH group, vessels area (VA) in CSPH group was smaller, and the total vessels length (TVL) was shorter (both P=0.027). The AUC of VA and TVL for diagnosing liver cirrhosis complicated with CSPH was 0.717 and 0.743, respectively. Conclusion SR CEUS was helpful for non-invasive diagnosis of liver cirrhosis complicated with CSPH. |
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