| 付瑶,李博,张翠,李育玲,荆慧.显微超声造影(SR CEUS)鉴别乳腺良、恶性导管内病变[J].中国医学影像技术,2026,42(6):863~866 |
| 显微超声造影(SR CEUS)鉴别乳腺良、恶性导管内病变 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for differentiating benign and malignant intraductal lesions of breast |
| 投稿时间：2025-11-28 修订日期：2026-05-12 |
| DOI：10.13929/j.issn.1003-3289.2026.06.011 |
| 中文关键词: 癌,导管,乳腺 显微超声造影 |
| 英文关键词:carcinoma, ductal, breast super resolution contrast-enhanced ultrasound |
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| 中文摘要: |
| 目的 探讨显微超声造影(SR CEUS)鉴别乳腺良、恶性导管内病变的价值。方法 前瞻性收集49例乳腺导管内病变患者、共60个病变,根据SR CEUS定性(微血管形态)及定量参数[血管密度(VD)、血流速度(FV)、血管直径及灌注指数(PI)]判断病变性质。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),以病理结果为金标准,评估SR CEUS鉴别诊断乳腺良、恶性导管内病变的效能。结果 60个病变中,38个为良性(良性组)、22个为恶性(恶性组)。SR CEUS显示,良性组微血管形态多呈放射状或树枝状(24/38,63.16%);恶性组多血管丰富、呈混乱型或穿支状(19/22,86.36%)。恶性组VD、FV、血管直径及PI均高于良性组(P均＜0.05)。基于SR CEUS鉴别乳腺导管内良、恶性病变的敏感度、特异度、阳性预测值、阴性预测值及AUC分别为86.36%、86.84%、79.17%、91.67%及0.866(P＜0.05)。结论 SR CEUS用于鉴别乳腺良、恶性导管内病变具有良好效能。 |
| 英文摘要: |
| Objective To investigate the value of super resolution contrast-enhanced ultrasound (SR CEUS) for differentiating benign and malignant intraductal lesions of breast. Methods A total of 60 lesions from 49 patients with intraductal lesions of breast were prospectively enrolled. SR CEUS qualitative (microvascular morphology) and quantitative parameters (vascular density [VD], flow velocity [FV], vessel diameter, and perfusion index [PI]) of the lesions were analyzed, and the nature of lesions were assessed according to qualitative analysis and quantitative parameters results of SR CEUS. The receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) was calculated to evaluate the differential diagnostic efficacy of SR CEUS for benign and malignant intraductal lesions of breast, using pathological results as the gold standard. Results Among 60 lesions, 38 were benign (benign group) and 22 were malignant (malignant group). SR CEUS showed that the microvascular morphology of benign lesions were mostly radial or branched (24/38, 63.16%), while malignant lesions mostly characterized by abundant blood vessels, presenting as disordered or branch-like (19/22, 86.36%). VD, FV, vascular diameter and PI in malignant group were all higher than those in benign group (all P＜0.05). The sensitivity, specificity, positive predictive value, negative predictive value and AUC of SR CEUS for differentiating benign and malignant intraductal lesions of breast was 86.36%, 86.84%, 79.17%, 91.67% and 0.866 (P＜0.05), respectively. Conclusion SR CEUS had good efficacy for differentiating benign and malignant intraductal lesions of breast. |
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