| 王子清,李娟娟,纪晓惠.成像帧频对显微超声造影(SR CEUS)乳腺肿块定量参数的影响[J].中国医学影像技术,2026,42(6):850~853 |
| 成像帧频对显微超声造影(SR CEUS)乳腺肿块定量参数的影响 |
| Impact of frame rate on super resolution contrast-enhanced ultrasound (SR CEUS) quantitative parameters of breast mass |
| 投稿时间：2025-11-28 修订日期：2026-04-18 |
| DOI：10.13929/j.issn.1003-3289.2026.06.008 |
| 中文关键词: 乳腺肿瘤 血流动力学 成像帧频 超声检查 显微超声造影 |
| 英文关键词:breast neoplasms hemodynamics imaging frame rate ultrasonography super resolution contrast-enhanced ultrasound |
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| 中文摘要: |
| 目的 探讨成像帧频(FR)对于显微超声造影(SR CEUS)乳腺肿块定量参数的影响。方法 前瞻性连续纳入31例单发乳腺肿块患者,分别以500、330、220及110 Hz共4种FR行SR CEUS。对数据进行离线重建,获取病变血管密度(VD)、分形维数(FD)、血流容积(FWVD)及灌注指数(PI),通过速度分析(VA)获取平均速度(VA Mean)、最大速度(VA Max)、最小速度(VA Min)、平均速度绝对偏差(VA Med)及速度标准差(VA SD),通过强度分析(IA)获得ROI内的微泡最大累积强度(IA Max)、平均累积强度(IA Mean)、中值累积强度(IA Med)及累积强度标准差(IA SD)和微血管方向方差(Dir Var)等定量参数并进行重复测量方差分析,评估不同FR下上述参数鉴别良、恶性肿块的价值。结果 不同FR下SR CEUS间病变FD差异无统计学意义(F=1.989,P=0.121),而VD、FWVD及PI差异均有统计学意义(P均＜0.05);220 Hz、110 Hz与330 Hz下VD差异均有统计学意义(P均＜0.05)。FWVD及PI均随FR升高而呈递增趋势。随FR升高,VA Max、VA Mean及VA Med均呈递增趋势(P均＜0.05),而VA Min和VA SD均无规律性变化;IA Max、IA Mean、IA Med及IA SD亦均呈递增趋势(P均＜0.05)。最大累积强度随FR升高而增大,提示高FR可提升捕获微泡信号峰值能力。随FR升高,速度方差(Vel Var)呈递增趋势(P＜0.05),而方向方差(Dir Var)无规律性变化。220 Hz时,恶性肿块IA Max低于、而IA SD高于良性肿块(P均＜0.05)。结论 成像FR对乳腺肿块SR CEUS微血管形态学参数影响较小、而对功能学参数影响较大;高成像FR能显著提升测量血流动力学精确度;220 Hz可作为鉴别诊断乳腺良、恶性肿块的优选FR。 |
| 英文摘要: |
| Objective To investigate the impact of frame rates (FR) on super resolution contrast-enhanced ultrasound (SR CEUS) quantitative parameters of breast mass. Methods Totally 31 consecutive patients with single breast mass were prospectively enrolled. SR CEUS was performed under FR of 500, 330, 220 and 110 Hz, respectively. After offline reconstruction of images, quantitative parameters of the lesions, such as vascular density (VD), fractal dimension (FD), flow-weighted vessel density (FWVD), perfusion index (PI), velocity analysis (VA) (including average velocity [VA Mean], maximum velocity [VA Max], minimum velocity [VA Min], absolute deviation of average velocity [VA Med] and velocity standard deviation [VA SD]), intensity analysis (IA) (including maximum cumulative intensity [IA Max], average cumulative intensity [IA Mean], median cumulative intensity [IA Med], cumulative intensity standard deviation [IA SD] of microbubbles within ROI) and microvascular directional variance (Dir Var) were obtained and analyzed using repeated measures ANOVA. Further analysis of the above parameters under different FR for differential diagnosis of benign and malignant mass was then conducted. Results Among SR CEUS with 4 different FR, no significant difference of FD was found (F=1.989, P=0.121), while VD, FWVD and PI were all significantly different (all P＜0.05). Compared with 330 Hz SR CEUS, significant differences of VD were detected between SR CEUS under 220 Hz and 110 Hz (both P＜0.05). With the rise of FR, both FWVD and PI showed trend of increase, so did VA Max, VA Mean and VA Med (all P＜0.05), while VA Min and VA SD did not show regular changes. IA Max, IA Mean, IA Med and IA SD all showed increase trend with the rise of FR (all P＜0.05). The maximum cumulative intensity increased with the increase of FR, indicating that high FR could improve peak capture ability of signals of microbubbles. Vel Var showed an increasing trend with the increase of FR (P＜0.05), while Dir Var showed no regular changes. For 220 Hz SR CEUS, IA Max of malignant mass was lower, while IA SD was higher than those of benign mass (both P＜0.05). Conclusion FR had relatively small impact on microvascular morphological parameters, but significant impact on functional parameters of SR CEUS of breast mass. High FR could significantly improve the accuracy of hemodynamic measurements, and 220 Hz could be regarded as the preferred FR for differential diagnosis of benign and malignant breast mass. |
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