| 王连双,韩帆,刘金昊,马晨瑶,徐帅娅,王米雪,倪亮,张瑶.显微超声造影(SR CEUS)用于定性诊断HIV相关浅表淋巴结病变[J].中国医学影像技术,2026,42(6):845~849 |
| 显微超声造影(SR CEUS)用于定性诊断HIV相关浅表淋巴结病变 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for qualitative diagnosis of HIV-related superficial lymph node lesions |
| 投稿时间：2025-11-30 修订日期：2026-03-15 |
| DOI：10.13929/j.issn.1003-3289.2026.06.007 |
| 中文关键词: 人类免疫缺陷病毒 淋巴结 显微超声造影 前瞻性研究 |
| 英文关键词:HIV lymph node super resolution contrast-enhanced ultrasound prospective studies |
| 基金项目:临床研究和科研创新转化专病队列项目(KCDL202404)、徐州市第七人民医院院级科研项目(DTXZ202403)。 |
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| 中文摘要: |
| 目的 探讨显微超声造影(SR CEUS)用于定性诊断HIV相关浅表淋巴结病变的价值。方法 前瞻性纳入接受浅表淋巴结穿刺的连续21例HIV患者,根据病理结果分为良性组(n=15)与恶性组(n=6)。行SR CEUS检查,记录病变微血管参数,包括血管密度(VD)、分形维数(FD)、灌注指数(PI)、最大强度(Max Inten)、平均强度(Mean Inten)、中值强度(Med Inten)、强度标准差(Inten SD)、最大速度(Max Vel)、最小速度(Min Vel)、平均速度(Mean Vel)、中值速度(Med Vel)、速度标准差(Vel SD)、速度方差(Vel Var)及方向方差(Dir Var)并进行组间比较。绘制受试者工作特征(ROC)曲线,基于曲线下面积(AUC)评估上述参数鉴别良、恶性HIV相关浅表淋巴结病变的效能。结果 恶性组VD和Med Inten均低于良性组(P均＜0.05),其余参数组间差异均无统计学意义(P均＞0.05)。VD和Med Inten鉴别良、恶性HIV相关浅表淋巴结病变的AUC分别为0.856和0.856。结论 SR CEUS用于鉴别良、恶性HIV相关浅表淋巴结病变具有一定价值。 |
| 英文摘要: |
| Objective To explore the value of super resolution contrast-enhanced ultrasound (SR CEUS) for qualitative diagnosis of HIV-related superficial lymph node lesions. Methods Twenty-one HIV patients who underwent superficial lymph node biopsy were prospectively enrolled and divided into benign group (n=15) and malignant group (n=6) according to pathological findings. SR CEUS was performed, the microvascular parameters of lesions, including vessel density (VD), fractal dimension (FD), perfusion index (PI), maximum intensity (Max Inten), mean intensity (Mean Inten), median intensity (Med Inten), intensity standard deviation (Inten SD), maximum velocity (Max Vel), minimum velocity (Min Vel), mean velocity (Mean Vel), median velocity (Med Vel), velocity standard deviation (Vel SD), velocity variance (Vel Var) and directional variance (Dir Var) were obtained and compared between groups. Receiver operating characteristic (ROC) curves were drawn, and the efficacy of the above parameters for differentiating benign and malignant HIV-related superficial lymph node lesions were evaluated based on the area under the curve (AUC). Results VD and Med Inten in malignant group were both lower than those in benign group (both P＜0.05), while no significant difference of other parameters was found between groups (all P＞0.05). The AUC of VD and Med Inten for differentiating benign and malignant HIV-related superficial lymph node lesions was 0.856 and 0.856, respectively. Conclusion SR CEUS had certain value for differentiating benign and malignant HIV-related superficial lymph node lesions. |
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