| 赵敏捷,韩雪迪,姜静思,牛皓月,崔立刚.显微超声造影(SR CEUS)用于鉴别良、恶性浅表淋巴结肿大[J].中国医学影像技术,2026,42(6):834~838 |
| 显微超声造影(SR CEUS)用于鉴别良、恶性浅表淋巴结肿大 |
| Super resolution contrast-enhanced ultrasound (SR CEUS) for differentiating benign and malignant superficial lymph node enlargement |
| 投稿时间：2025-11-15 修订日期：2026-04-17 |
| DOI：10.13929/j.issn.1003-3289.2026.06.005 |
| 中文关键词: 淋巴结病 显微超声造影 前瞻性研究 |
| 英文关键词:lymphadenopathy super resolution contrast-enhanced ultrasound prospective studies |
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| 中文摘要: |
| 目的 探讨显微超声造影(SR CEUS)鉴别良、恶性浅表淋巴结肿大的价值。方法 前瞻性纳入52例浅表淋巴结肿大患者,根据活检病理结果分为良性组(n=23)与恶性组(n=29);比较组间常规超声表现及SR CEUS定量参数。构建常规超声模型、SR CEUS模型及联合模型,以受试者工作特征曲线下面积(AUC)评价模型鉴别浅表淋巴结良、恶性病变的效能。结果 恶性组淋巴结门结构缺失占比高于良性组(P＜0.05);组间其他常规超声表现差异均无统计学意义(P均＞0.05)。恶性组淋巴结ROI面积、淋巴结周缘与中心血管密度比(VDR)及灌注指数比(PIR)均高于,而血管密度(VD)、血流容积(FWVD)、灌注指数(PI)、最大强度(Max Inten)、中值强度(Med Inten)、最小速度(Min Vel)及中值速度(Med Vel)均低于良性组(P均＜0.05)。常规超声模型、SR CEUS模型及联合模型鉴别浅表淋巴结良、恶性病变的AUC分别为0.693、0.817及0.852;联合模型的鉴别效能高于常规超声模型(P=0.020)而与SR CEUS模型差异无统计学意义(P=0.324)。结论 SR CEUS可作为常规超声的有效补充而用于鉴别良、恶性浅表淋巴结肿大。 |
| 英文摘要: |
| Objective To investigate value of super resolution contrast-enhanced ultrasound (SR CEUS) for differentiating benign and malignant superficial lymph node enlargement. Methods Fifty-two patients with enlarged superficial lymph nodes were prospectively enrolled and divided into benign group (n=23) and malignant group (n=29) according to pathological results of biopsy. Conventional ultrasound findings and quantitative SR CEUS parameters were compared between groups. Conventional ultrasound model, SR CEUS model and combined model were constructed, and their performance for differentiating benign and malignant superficial lymph node enlargement were evaluated using the area under the receiver operating characteristic curve (AUC). Results The proportion of lymph nodes with absent hilar structures in malignant group was higher than in benign group (P＜0.05), while no significant difference of other conventional ultrasound findings was observed between groups (all P＞0.05). In malignant group, ROI area, vessel density ratio (VDR) and perfusion index ratio (PIR) of peripheral to central regions of lymph node were all higher, whereas vessel density (VD), flow-weighted vessel density (FWVD), perfusion index (PI), maximum intensity (Max Inten), median intensity (Med Inten), minimum velocity (Min Vel) and median velocity (Med Vel) were all lower than those in benign group (all P＜0.05). The AUC of conventional ultrasound model, SR CEUS model and combined model for differentiating benign and malignant superficial lymph node enlargement was 0.693, 0.817 and 0.852, respectively. The performance of combined model was superior to that of conventional ultrasound model (P=0.020) but not significantly different with SR CEUS model (P=0.324). Conclusion SR CEUS could be used as an effective supplementation of conventional ultrasound for differentiating benign and malignant superficial lymph node enlargement. |
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