| 张莉,王亚红,李建初.显微超声造影(SR CEUS)研究进展及挑战[J].中国医学影像技术,2026,42(6):817~820 |
| 显微超声造影(SR CEUS)研究进展及挑战 |
| Super resolution contrast-enhanced ultrasound (SR CEUS):Progresses and challenges |
| 投稿时间：2026-04-16 修订日期：2026-05-16 |
| DOI：10.13929/j.issn.1003-3289.2026.06.001 |
| 中文关键词: 超声检查 显微超声造影 |
| 英文关键词:ultrasonography super resolution contrast-enhanced ultrasound |
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| 中文摘要: |
| 微循环功能异常是肿瘤、心血管疾病等多种疾病的核心病理改变之一。受衍射极限的物理制约,常规超声难以满足临床评估微血管血流需要。显微超声造影(SR CEUS)技术的出现为评估微循环提供了全新的手段;且经过持续迭代,其成像时长等关键瓶颈已得到逐步优化。目前SR CEUS用于评估组织功能、诊疗肿瘤及血管疾病等已取得临床前与初步临床成果,但仍处于临床转化的关键探索期,面临方法学不统一、运动伪影致图像质量不满意等核心挑战。本文系统梳理SR CEUS技术演进、临床前验证与临床应用现状,分析现存关键问题,并展望其未来实现标准化与大规模临床转化路径。 |
| 英文摘要: |
| Microcirculatory dysfunction is a core pathological alteration underlying various major diseases, such as tumors and cardiovascular diseases. Physically constrained by the diffraction limit, conventional ultrasound is difficult to meet clinical demands for assessing microvascular blood flow. The emergence of super resolution contrast-enhanced ultrasound (SR CEUS) provides a powerful new tool for evaluation on microcirculation. After continuous iteration, SR CEUS has gradually optimized key bottlenecks such as prolonged imaging duration. At present, SR CEUS has achieved notable preclinical and preliminary clinical results in the fields of tissue function assessment, diagnosis and treatment of tumors and vascular diseases, but still remains in the critical exploration period of transitioning from laboratory research to clinical application, facing core challenges such as inconsistent methodology and unsatisfactory imaging quality caused by motion artifacts. The technological evolution, preclinical validation and clinical application status of SR CEUS were systematically reviewed, the existing key issues was analyzed, and the future path of standardization and large-scale clinical translation were looked forward in this article. |
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