| 易栏,张体江.MRI研究阿尔茨海默病脑-肠轴作用机制进展[J].中国医学影像技术,2026,42(5):782~785 |
| MRI研究阿尔茨海默病脑-肠轴作用机制进展 |
| Progresses in MRI researches of mechanism of gut-brain axis in Alzheimer disease |
| 投稿时间：2025-10-14 修订日期：2026-01-18 |
| DOI：10.13929/j.issn.1003-3289.2026.05.027 |
| 中文关键词: 阿尔茨海默病 脑-肠轴 胃肠道微生物组 磁共振成像 |
| 英文关键词:Alzheimer disease brain-gut axis gastrointestinal microbiome magnetic resonance imaging |
| 基金项目:贵州省科技计划 、贵州省教育厅智能医学影像工程研究中心建设项目(黔教技[2023]038号)、毕节市第七批人才团队(毕委人领办通[2025]8号)。 |
|
| 摘要点击次数: 101 |
| 全文下载次数: 67 |
| 中文摘要: |
| 脑-肠轴(GBA)是肠道与中枢神经系统(CNS)之间的双向调控网络;肠道菌群为GBA重要环节,可维持肠道稳态、调节肠道功能,通过神经、免疫和代谢途径影响大脑功能,与阿尔茨海默病(AD)发生、进展存在一定关联。多模态MRI可无创反映脑结构、功能及代谢等多维度信息,为研究肠道菌群如何通过GBA影响AD脑改变提供了独特视角。本文围绕MRI研究GBA在AD中 的作用机制进展进行综述。 |
| 英文摘要: |
| The gut-brain axis (GBA) constitutes a bidirectional communication network between gut and central nervous system (CNS). Serving as a crucial component of GBA, gut microbiota maintains intestinal homeostasis, modulates gut function and impacts brain function through neural, immune and metabolic pathways, also associated with the occurrence and progression of Alzheimer disease (AD). Multimodal MRI can noninvasively reflect multidimensional information of brain structure, function and metabolism, hence providing insights into GBA-mediated mechanisms underlying AD-related neuropathology. The progresses in MRI researches of mechanism of GBA in AD were reviewed in this article. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
