| 张春雷,张竹青,赵晗,吴俊宇,黄凯,刘学军.强迫症脑功能损伤核心机制[J].中国医学影像技术,2026,42(5):692~697 |
| 强迫症脑功能损伤核心机制 |
| Core pathological mechanisms of brain function damage in obsessive-compulsive disorder |
| 投稿时间：2025-09-11 修订日期：2025-11-30 |
| DOI：10.13929/j.issn.1003-3289.2026.05.008 |
| 中文关键词: 强迫症 磁共振成像 默认网络 功能连接 |
| 英文关键词:obsessive-compulsive disorder magnetic resonance imaging default mode network functional connectivity |
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| 中文摘要: |
| 目的 通过定位观察探讨强迫症(OCD)脑功能损伤核心机制。方法 依据系统评价和荟萃分析优先报告条目(PRISMA)筛选 31篇静息态功能MRI(rs-fMRI)文献,含40组对比数据,共1 459例OCD(OCD组);另以来自2个数据库的1 758名健康成人作为对照(HC组)。提取rs-fMRI核心指标,通过功能连接网络映射(FCNM)构建并分析静息态异常功能网络。结果 OCD组双侧内侧前额叶皮层、尾状核及额中回存在显著功能连接异常,涉及默认网络、额顶叶控制网络(FPCN)及皮质-纹状体-丘脑-皮质(CSTC)回路。结论 OCD核心病理机制在于默认网络过度活跃、FPCN调控失调及CSTC回路功能亢进交互失衡。 |
| 英文摘要: |
| Objective To explore the core pathological mechanisms of brain function damage in obsessive-compulsive disorder (OCD). Methods Totally 31 resting-state functional MRI (rs-fMRI) articles reported 40 groups of comparative data, including 1 459 patients with OCD (OCD group) were screened based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, and 1 758 healthy adults from 2 databases were taken as healthy controls (HC group). The core rs-fMRI indicators were extracted, and abnormal resting-state functional network was constructed and analyzed through functional connectivity network mapping (FCNM). Results Significant abnormal functional connections in bilateral medial prefrontal cortex, caudate nucleus and middle frontal gyrus were found in OCD group, which involved the default mode network, the fronto-parietal control network (FPCN) and the cortico-striatal-thalamic-cortical (CSTC) circuit. Conclusion The core pathological mechanisms of brain function damage in OCD lied in the interaction imbalance of overactive default mode network, dysregulation of FPCN and hyperfunction of CSTC circuit. |
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