| 谢聪,尹金辉,黄越,段云云.化学交换饱和转移成像评估亨廷顿病[J].中国医学影像技术,2026,42(5):687~691 |
| 化学交换饱和转移成像评估亨廷顿病 |
| Chemical exchange saturation transfer imaging for evaluating Huntington disease |
| 投稿时间：2026-04-27 修订日期：2026-05-15 |
| DOI：10.13929/j.issn.1003-3289.2026.05.007 |
| 中文关键词: 亨廷顿病 磁共振成像 化学交换饱和转移 |
| 英文关键词:Huntington disease magnetic resonance imaging chemical exchange saturation transfer |
| 基金项目:国家重点研发计划主动健康和老龄化科技应对重点专项(2022YFC2009900、2022YFC2009904)。 |
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| 中文摘要: |
| 目的 初步观察化学交换饱和转移成像(CEST)评估亨廷顿病(HD)的价值。方法 前瞻性纳入18例经基因检测确诊的HD患者(HD组),对其进行临床评分,包括胞嘧啶-腺嘌呤-鸟嘌呤年龄产物(CAP)、最大舞蹈症状、统一亨廷顿病评分量表(UHDRS)、总功能能力(TFC)、贝克抑郁自评量表(BDI)及数字符号模式测验(SDMT)评分;以18名健康人为健康对照组(HC组)。对2组采集3D T1WI及3D CEST;分别提取尾状核、壳核、苍白球及丘脑三维掩模内不对称磁化转移率的最大值(MTRasym_max)、最小值(MTRasym_min)及均值(MTRasym_mean)。采用方差分析比较HD组基底节各脑区间的代谢差异;以配对t检验比较组间各脑区MTRasym信号值差异;利用趋势图评估HD患者 CEST信号值与临床评分的关联。结果 HD组基底节各脑区代谢存在不一致性(P=0.047、0.006、0.001);其苍白球和丘脑MTRasym_max值均显著高于,而尾状核、壳核、苍白球及丘脑MTRasym_min值均显著低于HC组(P均＜0.03)。组间尾状核、壳核、苍白球、丘脑MTRasym_mean值,以及尾状核、壳核MTRasym_max值差异均无统计学意义(P均＞0.03)。趋势图显示,HD患者CEST信号值与CAP、最大舞蹈症状、UHDRS、TFC、BDI及SDMT评分均呈非线性相关(P均＜0.05)。结论 CEST信号值可作为无创评估HD的神经影像学标志物。 |
| 英文摘要: |
| Objective To preliminarily investigate the value of chemical exchange saturation transfer imaging (CEST) for evaluating Huntington disease (HD). Methods Eighteen HD patients (HD group) confirmed with genetic testing were prospectively enrolled. Clinical evaluation, including cytosine-adenine-guanine-age-product (CAP), maximal chorea, unified Huntington’s disease rating scale (UHDRS), total functional capability (TFC), Beck depression inventory (BDI) and symbol digit modalities test (SDMT) scores were performed in HD group. And 18 healthy individuals were selected as the healthy control group (HC group). Three-dimensional (3D) T1WI and 3D CEST were acquired in both groups. The maximum, minimum and mean magnetic transfer ratio asymmetry (MTRasym_max, MTRasym_min, MTRasym_mean) of the caudate nucleus, putamen, globus pallidus and thalamus in 3D masks were extracted. Analysis of variance was used to assess metabolic differences across different brain regions of the basal ganglia in HD group. Paired t tests were performed to compare MTRasym values of each region between groups. Trend charts were used to explore the associations of CEST signal values and various clinical scores. Results Metabolic heterogeneity was observed across regions of basal ganglia in HD group (P=0.047, 0.006, 0.001). MTRasym_max of globus pallidus and thalamus were significantly higher in HD group, while MTRasym_min of the caudate nucleus, putamen, globus pallidus and thalamus were significantly lower than those in HC group (all P＜0.03). No significant difference of MTRasym_mean of caudate nucleus, putamen, globus pallidus and thalamus, nor of MTRasym_max of caudate nucleus and putamen was found between groups (all P＞0.03). The trend charts demonstrated nonlinear correlations of CEST signal values and CAP, maximal chorea, UHDRS, TFC, BDI and SDMT scores in HD patients (all P＜0.05). Conclusion CEST signal value could serve as noninvasive neuroimaging biomarkers for evaluating HD. |
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