| 黄可忻,刘衡,冉海峰,徐高强,陈静,曾珍,易栏,周豪,张体江.伴中央颞区棘波自限性癫痫患儿灰质与白质功能网络变化[J].中国医学影像技术,2026,42(5):677~681 |
| 伴中央颞区棘波自限性癫痫患儿灰质与白质功能网络变化 |
| Gray and white matter functional networks changes in self-limited epilepsy children with centrotemporal spikes |
| 投稿时间：2026-01-23 修订日期：2026-05-08 |
| DOI：10.13929/j.issn.1003-3289.2026.05.005 |
| 中文关键词: 癫痫,颞叶 灰质 白质 功能神经影像学 磁共振成像 |
| 英文关键词:epilepsy, temporal lobe gray matter white matter functional neuroimaging magnetic resonance imaging |
| 基金项目:贵州省高等学校智能医学影像工程研究中心建设项目([2023]038号)、贵州省科技计划(黔科合人才CXTD[2025]047)、贵州省基础研究计划面上项目 、遵义市科技创新人才团队项目(遵市科人才〔2024〕5号)。 |
| 作者 | 单位 | E-mail | | 黄可忻 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 刘衡 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 冉海峰 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 徐高强 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 陈静 | 遵义医科大学附属医院儿童神经遗传内分泌科, 贵州 遵义 563000
贵州省儿童神经疾病临床研究中心, 贵州 遵义 563000 | | | 曾珍 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 易栏 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 周豪 | 遵义医科大学附属医院放射科, 贵州 遵义 563000 | | | 张体江 | 遵义医科大学附属医院放射科, 贵州 遵义 563000
毕节医学高等专科学校医学技术系, 贵州 毕节 551700 | tijzhang@163.com |
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| 中文摘要: |
| 目的 观察伴中央颞区棘波的自限性癫痫(SeLECTS)患儿灰质(GM)与白质(WM)功能网络变化。方法 回顾性纳入69例SeLECTS患儿(SeLECTS组)及66名健康对照(HC)组。基于K-means聚类算法识别稳定的GM与WM功能网络。比较组间GM、WM及GM-WM功能网络连接强度的差异;分析异常功能网络连接指标与 |
| 英文摘要: |
| Objective To investigate gray matter (GM) and white matter (WM) functional networks changes in self-limited epilepsy children with centrotemporal spikes (SeLECTS). Methods A total of 69 children with SeLECTS (SeLECTS group) and 66 healthy controls (HC group) were retrospectively enrolled. K-means clustering was applied to identify functional networks. Connectivity differences were assessed between groups. Correlations between aberrant network connectivity and clinical variables (Wechsler Intelligence Scale for Children scores, disease duration and seizure onset age) were evaluated. Results Eight GM functional networks and eight WM functional networks were identified, respectively. Compared with HC group, SeLECTS group exhibited significantly increased intra-network connectivity, alongside decreased connectivity among multiple GM networks and reduced GM-WM connectivity (all adjusted P＜0.05). Performance intelligence quotient (PIQ) score was positively correlated with WM4-GM7 connectivity strength, while earlier seizure onset age was negatively correlated with multiple GM connections and GM-WM connectivity. Conclusion Children with SeLECTS exhibited whole-brain scale functional network connectivity dysfunction, characterized by impairment across GM-WM networks. |
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