| 陈茜彤,蔡程锋,林于晴,李小纯,王育凯,陈绍琦.微纳米马达系统用于治疗类风湿关节炎研究进展[J].中国医学影像技术,2026,42(3):462~465 |
| 微纳米马达系统用于治疗类风湿关节炎研究进展 |
| Research progresses of micro/nanomotor systems in treatment of rheumatoid arthritis |
| 投稿时间：2025-10-20 修订日期：2026-01-05 |
| DOI：10.13929/j.issn.1003-3289.2026.03.029 |
| 中文关键词: 关节炎,类风湿 微纳米马达 分子靶向治疗 |
| 英文关键词:arthritis,rheumatoid micro/nanomotor molecular targeted therapy |
| 基金项目:2024年度广东省基础与应用基础研究基金(2024A1515220034)。 |
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| 中文摘要: |
| 靶向治疗类风湿关节炎(RA)面临诸多挑战。微纳米马达(MNM)受外场驱动或化学驱动而实现自主运动,可显著提升药物在关节炎症部位的富集与穿透能力,为RA治疗提供了新的途径。超声不仅能作为驱动MNM的物理场,更是MNM相关RA治疗中的实时、便捷的成像工具。本文围绕不同驱动方式的MNM系统用于治疗RA研究进展进行综述。 |
| 英文摘要: |
| Targeted therapy of rheumatoid arthritis (RA) faces many challenges. Under external fields driven or chemical driven, micro/nanomotor (MNM) can realize autonomously movement, hence significantly increasing drug accumulation and penetration in joint inflammatory sites, offering a novel approach for treating RA. Ultrasound can not only be used as the physical field driving MNM, but also as a real-time, convenient imaging tool in MNM related targeted therapy of RA. The research progresses of MNM systems based on different driving mechanisms for treating RA were reviewed in this article. |
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