| 荣萍,杨旭,辛小燕,冯倩倩,杨阳,林增萍,朱红燕,周科峰,杨雯.基于融合多回波3D超短回波时间氧气增强T2* mapping评估肺功能[J].中国医学影像技术,2026,42(3):347~350 |
| 基于融合多回波3D超短回波时间氧气增强T2* mapping评估肺功能 |
| Fusion multi-echo 3D-ultrashort echo time oxygen-enhanced T2* mapping for evaluating lung function |
| 投稿时间：2025-06-16 修订日期：2026-01-22 |
| DOI：10.13929/j.issn.1003-3289.2026.03.006 |
| 中文关键词: 肺 磁共振成像 氧气增强 前瞻性研究 |
| 英文关键词:lung magnetic resonance imaging oxygen-enhanced prospective studies |
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| 中文摘要: |
| 目的 观察融合多回波的3D-超短回波时间(UTE)氧气增强T2* mapping用于评估肺功能的价值。方法 前瞻性以基于3个TE的3D-UTE技术对15名健康志愿者采集常氧及高氧(吸入浓度100%氧气)条件下肺部T2* mapping,通过信号衰减曲线拟合计算肺部T2*值;分别记录左肺上、下叶及右肺上、中、下叶T2*值,以脊髓作为参照对T2*值进行归一化,计算相对T2*(rT2*)值并记录其中位数及四分位距(IQR);比较常氧与高氧条件下全肺及各肺叶rT2*值的中位数及其IQR差异。结果 常氧及高氧条件下,肺部rT2*值的中位数分别为0.19(0.17,0.25)及0.18(0.16,0.23),高氧条件下rT2*值降低(W=-72,P=0.041);常氧及高氧条件下肺部rT2*值的IQR分别为0.10±0.03及0.08±0.02,高氧条件下IQR降低(t=2.939,P=0.011)。常氧与高氧条件下各肺叶rT2*值的中位数及IQR差异均无统计学意义(P均＞0.05)。结论 基于融合多回波3D-UTE氧气增强T2* mapping可无创评估肺功能。 |
| 英文摘要: |
| Objective To observe the value of fusion multi-echo 3D-ultrashort echo time (UTE) oxygen-enhanced T2* mapping for evaluating lung function. Methods Fifteen healthy volunteers were prospectively enrolled and underwent pulmonary 3D UTE T2* mapping under normoxic and hyperoxic (100% oxygen inhalation) conditions based on three TE. Pulmonary T2* values were calculated by fitting signal attenuation curves, and T2* values of the upper and lower lobes of the left lung, as well as upper, middle and lower lobes of the right lung were recorded. Then T2* values were normalized using spinal cord as a reference to calculate relative T2* (rT2*) values, and the median and interquartile range (IQR) of rT2* values were recorded, and the median and IQR of rT2* values of the whole lung and each lobe were compared between normoxic and hyperoxic conditions. Results The median of rT2* values of the whole lung under normoxic and hyperoxic conditions was 0.19 (0.17, 0.25) and 0.18 (0.16, 0.23), respectively, the median of rT2* values decreased under hyperoxic condition (W=-72, P=0.041). IQR of rT2* values of the whole lung under normoxic and hyperoxic conditions was 0.10±0.03 and 0.08±0.02, respectively, IQR of rT2* values decreased under hyperoxic condition (t=2.939, P=0.011). No significant difference of the median and IQR of rT2* values in each lung lobe was found between normoxic and hyperoxic conditions (all P＞0.05). Conclusion Fusion multi-echo 3D-UTE oxygen-enhanced T2* mapping could be used to non-invasively evaluate lung function. |
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