| 徐婺姿,张小安,宋昊,周甜,王钰冰,王雪源,宣德胜,廖俊杰,郭晶,邢庆娜.基于三维伪连续动脉自旋标记评估重度子痫前期早产儿脑发育及其与产前指标的相关性[J].中国医学影像技术,2025,41(12):2032~2036 |
| 基于三维伪连续动脉自旋标记评估重度子痫前期早产儿脑发育及其与产前指标的相关性 |
| Evaluating brain development in severe pre-eclampsia preterm infants based on 3D pseudo-continuous arterial spin labeling and analyzing correlations with antenatal parameters |
| 投稿时间：2025-08-01 修订日期：2025-12-04 |
| DOI：10.13929/j.issn.1003-3289.2025.12.020 |
| 中文关键词: 先兆子痫 婴儿,早产 动脉自旋标记 超声检查,产前 前瞻性研究 |
| 英文关键词:pre-eclampsia infant, premature arterial spin labeling ultrasonography, prenatal prospective studies |
| 基金项目:河南省科技发展计划(242102310307)、国家自然科学基金(82371929)。 |
| 作者 | 单位 | E-mail | | 徐婺姿 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 张小安 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 宋昊 | 郑州大学第三附属医院新生儿科, 河南 郑州 450052 | | | 周甜 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 王钰冰 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 王雪源 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 宣德胜 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 廖俊杰 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 郭晶 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | | | 邢庆娜 | 郑州大学第三附属医院放射科, 河南 郑州 450052 | 819533069@qq.com |
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| 中文摘要: |
| 目的 基于三维伪连续动脉自旋标记(3D-pCASL)评估重度子痫前期(SPE)早产儿脑发育,并分析其与产前指标的相关性。方法 前瞻性纳入51例早产儿,根据孕期有无SPE划分SPE组(n=25)与非SPE组(n=26)。于校正胎龄37~40周时行3D-pCASL,获取不同脑区脑血流量(CBF)并进行组间比较;以Pearson相关分析观察SPE组不同脑区CBF值与产前指标 及新生儿神经行为评估(NBNA)的相关性。结果 SPE组双侧半卵圆中心、右侧顶叶白质、左侧顶叶皮层灰质、右侧额叶白质、右侧尾状核头、左侧枕叶皮层灰质、双侧颞叶白质CBF均高于非SPE组(P均＜0.05);其双侧颞叶白质CBF与UA阻力指数(RI),右侧颞叶白质CBF与UA收缩期峰值流速/舒张末期流速(S/D),右侧尾状核头CBF与UA S/D、搏动指数(PI)及RI均呈低度负相关(r=－0.494~－0.399,P均＜0.05),左侧顶叶、左侧枕叶皮层灰质及右侧尾状核头CBF均与产妇产前48 h外周血CRP水平呈低度负相关(r=－0.466~－0.415,P均＜0.05),而不同脑区CBF与NBNA评分均无明显相关(P均＞0.05)。结论 基于3D-pCASL发现SPE可致早产儿部分脑区CBF升高,后者与产前48 h内胎儿UA血流频谱和母体CRP水平相关。 |
| 英文摘要: |
| Objective To evaluate brain development in severe pre-eclampsia (SPE) preterm infants using 3D pseudo-continuous arterial spin labeling (3D-pCASL), and to analyze the correlations with antenatal parameters. Methods Totally 51 premature infants were prospectively included and divided into SPE group (n=25) and non-SPE group (n=26) according to maternal SPE status during pregnancy. 3D-pCASL was performed at corrected gestational age of 37—40 weeks to obtain cerebral blood flow (CBF) in different brain regions, then intergroup comparison was conducted subsequently. Pearson correlation analysis was used to investigate the correlations between regional CBF of SPE group and antenatal parameters (including fetal umbilical artery Doppler indices and maternal peripheral blood C-reactive protein within 48 h before delivery) as well as neonatal behavioral neurological assessment (NBNA) scores. Results CBF in bilateral centrum semiovale, right parietal white matter, left parietal cortical gray matter, right frontal white matter, right caudate head, left occipital cortical gray matter and bilateral temporal white matter in SPE group were all higher than those in non-SPE group (all P＜0.05).Weakly negatively correlations were found between bilateral temporal white matter CBF with UA resistance index (RI), right temporal white matter CBF with UA systolic peak velocity/diastolic end velocity (S/D), right caudate head CBF with UA S/D, pulsatility index (PI) and RI in SPE group (r=－0.494—－0.399, all P＜0.05). CBF of left parietal, left occipital cortical gray matter and right caudate head were weakly negatively correlated with maternal CRP (r=－0.466—－0.415, all P＜0.05). No significant correlation was observed between CBF in different brain regions and NBNA score in SPE group (all P＞0.05). Conclusion 3D-pCASL demonstrated that SPE was associated with increased CBF in some brain regions in preterm infants, and those changes were correlated with fetal UA blood flow spectrum indices and maternal CRP levels within 48 h before delivery. |
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