| 李凌霄,彭希,李亥辰.阿霉素相关心脏毒性大鼠左心室心肌应变与血管生成障碍的相关性[J].中国医学影像技术,2025,41(12):1970~1975 |
| 阿霉素相关心脏毒性大鼠左心室心肌应变与血管生成障碍的相关性 |
| Correlation between left ventricular myocardial strain and impaired angiogenesis in rats with doxorubicin-induced cardiotoxicity |
| 投稿时间：2025-06-06 修订日期：2025-11-11 |
| DOI：10.13929/j.issn.1003-3289.2025.12.007 |
| 中文关键词: 大鼠 阿霉素 心脏毒性 血管生成 磁共振成像 |
| 英文关键词:rats doxorubicin cardiotoxicity angiogenesis magnetic resonance imaging |
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| 中文摘要: |
| 目的 观察阿霉素相关心脏毒性(DIC)大鼠左心室心肌应变与血管生成障碍的相关性。方法 将24只SD大鼠随机分为麝香保心丸组(A组)、DIC组(B组)及对照组(C组),每组8只。对A、B组注射阿霉素(DOX)溶液2.5 mg/kg体质量,对C组注射等量生理盐水,每周1次、持续6周;同时对A组予麝香保心丸混悬液28 mg/kg体质量灌胃,B、C组予等量蒸馏水灌胃,每日1次、持续6周。以7.0T MR仪扫描大鼠心脏,获取其左心室参数。对左心室心肌组织行病理学检查,检测微血管密度(MVD)、血管内皮生长因子(VEGF)和内皮型一氧化氮合酶(eNOS)表达;分析左心室心肌应变参数与上述病理学指标的相关性。结果 3组大鼠左心室收缩末期容积(LVESV)、左心室射血分数(LVEF)及左心室整体纵向应变(LVGLS),以及MVD、VEGF平均光密度(AOD)及eNOS AOD差异均有统计学意义(P均＜0.05)。B组LVGLS与MVD、VEGF AOD及eNOS AOD均呈负相关(P均＜0.05)。结论 DIC大鼠LVGLS与MVD、VEGF AOD及eNOS AOD均呈负相关。 |
| 英文摘要: |
| Objective To observe the correlation between left ventricular myocardial strain and impaired angiogenesis in rats with doxorubicin-induced cardiotoxicity (DIC). Methods Twenty-four SD rats were randomly divided into Shexiang Baoxin pill group (group A), DIC group (group B) and control group (group C) (each n=8). Rats in group A and B were injected with doxorubicin (DOX) solution 2.5 mg/kg body mass, while those in group C were injected with equal volume of physiological saline solution once a day for 6 weeks. Concurrently, rats in group A underwent Shexiang Baoxin pill suspension 28 mg/kg body mass by gavage, in group B and C received equal volume of physiological saline solution by gavage once a day for 6 weeks. 7.0T cardiac MR scanning was performed to obtain left ventricular parameters. Then the left ventricular myocardial tissue was taken for pathological examination, and the microvascular density (MVD), vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) expression were detected. The correlation between left ventricular myocardial strain parameters and the above pathological indicators were analyzed. Results Significant differences of left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LVGLS), also of MVD, average optical density (AOD) of VEGF and eNOS were found among 3 groups (all P＜0.05). In group B, LVGLS was negatively correlated with MVD, VEGF AOD and eNOS AOD (all P＜0.05). Conclusion LVGLS was negatively correlated with MVD, VEGF AOD and eNOS AOD in DIC rats. |
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