| 张世翔,高金,卫一丹,富丽萍.18 kDa转位蛋白(TSPO)-PET显像用于神经退行性疾病:进展与挑战[J].中国医学影像技术,2025,41(10):1750~1754 |
| 18 kDa转位蛋白(TSPO)-PET显像用于神经退行性疾病:进展与挑战 |
| Advances and challenges of 18 kDa translocator protein (TSPO)-PET imaging in neurodegenerative diseases |
| 投稿时间：2025-04-16 修订日期：2025-10-10 |
| DOI：10.13929/j.issn.1003-3289.2025.10.031 |
| 中文关键词: 神经变性疾病 正电子发射断层显像 18 kDa转位蛋白 |
| 英文关键词:neurodegenerative diseases positron-emission tomography 18 kDa translocator protein |
| 基金项目:中日友好医院高水平医院临床业务费专项成果转化项目(2023-NHLHCRF-YXHZ-ZRZD-01)。 |
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| 中文摘要: |
| 神经退行性疾病(NDD)是一组以神经元退化和功能丧失为特征的异质性疾病,神经炎症在其发生发展过程中发挥重要作用。18 kDa转位蛋白(TSPO)表达水平与小胶质细胞和星形胶质细胞活化密切相关,被视为神经炎症指标之一。TSPO-PET为非侵入性动态监测脑内神经炎症时空分布的分子影像学方法,为早期诊断NDD、预测疾病进展及评估疗效提供重要依据。本文就TSPO-PET显像用于NDD进展与挑战进行综述。 |
| 英文摘要: |
| Neurodegenerative diseases (NDD) are a heterogeneous group of disorders characterized by neuronal degeneration and functional impairment, in which neuroinflammation plays a pivotal role throughout disease onset and progression. The 18 kDa translocator protein (TSPO) serves as an important molecular biomarker of neuroinflammation, with its expression closely associated with activation of microglia and astrocytes. TSPO-PET enables noninvasive and dynamic mapping of spatiotemporal distribution of cerebral neuroinflammation, providing crucial molecular imaging evidence for early diagnosis, disease evaluation and therapeutic response assessment of NDD. The advances and challenges of TSPO-PET imaging in NDD were reviewed in this article. |
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