| 申磊,付芳芳,代博,杨天云,窦社伟.基于弥散加权成像、酰胺质子转移加权成像及葡萄糖化学交换饱和转移成像预测直肠癌淋巴结转移[J].中国医学影像技术,2025,41(10):1696~1700 |
| 基于弥散加权成像、酰胺质子转移加权成像及葡萄糖化学交换饱和转移成像预测直肠癌淋巴结转移 |
| Diffusion-weighted imaging, amide proton transfer-weighted imaging and glucose chemical exchange saturation transfer imaging for predicting lymph node metastasis of rectal cancer |
| 投稿时间：2025-03-29 修订日期：2025-10-13 |
| DOI：10.13929/j.issn.1003-3289.2025.10.019 |
| 中文关键词: 直肠肿瘤 淋巴转移 磁共振成像 化学交换饱和转移 |
| 英文关键词:rectal neoplasms lymphatic metastasis magnetic resonance imaging chemical exchange saturation transfer |
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| 摘要点击次数: 129 |
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| 中文摘要: |
| 目的 观察弥散加权成像(DWI)、酰胺质子转移加权成像(APTWI)和葡萄糖化学交换饱和转移成像(glucoCEST)预测直肠癌淋巴结转移的价值。方法 回顾性纳入60例经病理证实的直肠癌,根据有无淋巴结转移分为转移组(n=36)与非转移组(n=24);分别基于DWI、APTWI及glucoCEST获取病灶表观弥散系数(ADC)值及3.50 ppm和1.20 ppm处非对称磁化转移率(MTRasym3.50 ppm、MTRasym1.20 ppm)值并进行组间比较;绘制受试者工作特征曲线,计算曲线下面积(AUC),评估各单一参数及其联合预测直肠癌淋巴结转移的效能。结果 转移组病灶ADC值低于,而MTRasym3.50 ppm和MTRasym1.20 ppm值均高于非转移组(P均＜0.05)。ADC、MTRasym3.50 ppm及MTRasym1.20 ppm值联合预测直肠癌淋巴结转移的AUC达0.970,显著高于各单一参数(AUC分别为0.858、0.804及0.755,Z=2.442~3.231,P均＜0.05)。结论 DWI、APTWI及glucoCEST均可用于预测直肠癌淋巴结转移;联合ADC、MTRasym3.50 ppm及MTRasym1.20 ppm进行预测的效能最高。 |
| 英文摘要: |
| Objective To explore the value of diffusion-weighted imaging (DWI), amide proton transfer-weighted imaging (APTWI) and glucose chemical exchange saturation transfer imaging (glucoCEST) for predicting lymph node metastasis of rectal cancer. Methods Sixty cases of rectal cancer confirmed by pathology were retrospectively enrolled and divided into metastasis group (n=36) and non-metastasis group (n=24) based on the presence or absence of lymph node metastasis. The apparent diffusion coefficient (ADC) value, as well as the values of magnetization transfer ratio asymmetry at 3.50 ppm and 1.20 ppm (MTRasym3.50 ppm and MTRasym1.20 ppm) of the lesions were respectively obtained based on DWI, APTWI and glucoCEST and then compared between groups. Receiver operating characteristic curve was drawn, the area under the curve (AUC) was calculated to evaluate the efficacy of each parameter alone and their combination for predicting lymph node metastasis of rectal cancer. Results In metastasis group, ADC value of the lesions was lower, while MTRasym3.50 ppm and MTRasym1.20 ppm values were both higher than those in non-metastasis group (all P＜0.05). AUC of the combination of the above parameters for predicting lymph node metastasis of rectal cancer based on ADC, MTRasym3.50 ppm and MTRasym1.20 ppm values was 0.970, significantly higher than that of each single parameter (0.858, 0.804 and 0.755, respectively; Z=2.442—3.231, all P＜0.05). Conclusion DWI, APTWI and glucoCEST could all be used to predicte lymph node metastasis of rectal cancer. Combination of ADC, MTRasym3.50 ppm and MTRasym1.20 ppm had the highest predictive efficacy. |
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